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首页> 外文期刊>Biochimica et biophysica acta. Biomembranes >Development of wrapped liposomes: Novel liposomes comprised of polyanion drug and cationic lipid complexes wrapped with neutral lipids
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Development of wrapped liposomes: Novel liposomes comprised of polyanion drug and cationic lipid complexes wrapped with neutral lipids

机译：包裹脂质体的开发：由聚阴离子药物和包裹有中性脂质的阳离子脂质复合物组成的新型脂质体

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Novel wrapped liposomes comprised of polyanion drug and cationic lipid complexes wrapped with neutral lipids were prepared using an efficient, innovative procedure. In this study, dextran fluorescein anionic (DFA) was used as an example of apolyanionic compound. During the process, neutral lipids accumulated around the complexes and eventually covered the complexes. The resulting liposomes were 120-140 nm in diameter and the encapsulation efficiency was up to 90%. In fetal bovine serum, DFA/cationic lipid complexes degraded rapidly but the wrapped liposomes were considerably more stable. Following intravenous administration to rats, DFA/cationic lipid complexes were rapidly eliminated whereas the wrapped liposomes exhibited a much longer blood half-life. These data suggest that DFA is located on the surface of the complexes, but DFA is present inside the wrapped liposomes. The drug-delivery properties of the wrapped liposomes established in the present study suggests that formulations based on this technology could offer important advantages for the administration of many types of drug including antisense oligonucleotides, plasmids and siRNAs which may therefore lead to improved therapeutic effectiveness of this range of drugs. The method of preparation of the wrapped liposomes is so simple that it should be straightforward to adapt to a manufacturing scale. (c) 2006 Elsevier B.V. All fights reserved.
机译：使用高效，创新的方法制备了由聚阴离子药物和包裹有中性脂质的阳离子脂质复合物组成的新型包裹脂质体。在这项研究中，葡聚糖荧光素阴离子（DFA）被用作聚阴离子化合物的一个例子。在此过程中，中性脂质聚集在复合物周围并最终覆盖复合物。所得脂质体的直径为120-140nm，并且包封效率高达90％。在胎牛血清中，DFA /阳离子脂质复合物迅速降解，但包裹的脂质体则更加稳定。向大鼠静脉内给药后，DFA /阳离子脂质复合物被迅速清除，而包裹的脂质体则具有更长的血液半衰期。这些数据表明DFA位于复合物的表面，但DFA存在于包裹的脂质体内。在本研究中建立的包裹脂质体的药物传递特性表明，基于该技术的制剂可为多种类型的药物（包括反义寡核苷酸，质粒和siRNA）的给药提供重要的优势，因此可改善该药物的治疗效果药物范围。包裹的脂质体的制备方法非常简单，以使其易于适应生产规模。 （c）2006年Elsevier B.V.版权所有。

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