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首页> 外文期刊>Epilepsia: Journal of the International League against Epilepsy >Anxiety disorders, subsyndromic depressive episodes, and major depressive episodes: do they differ on their impact on the quality of life of patients with epilepsy?
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Anxiety disorders, subsyndromic depressive episodes, and major depressive episodes: do they differ on their impact on the quality of life of patients with epilepsy?

机译：焦虑症，亚症状性抑郁发作和重度抑郁发作：它们对癫痫患者生活质量的影响是否有所不同？

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AIMS OF THE STUDY: To compare the impact of anxiety disorders, major depressive episodes (MDEs), and subsyndromic depressive episodes (SSDEs) on the quality of life of patients with epilepsy (PWEs), and to identify the variables predictive of poor quality of life. METHODS: A psychiatric diagnosis according to DSM-IV-TR criteria was established in 188 consecutive PWEs with the MINI International Neuropsychiatric Interview. Patients also completed the Beck Depression Inventory-II (BDI-II), the Centers for Epidemiologic Studies-Depression (CES-D), and the Quality of Life in Epilepsy-89 (QOLIE-89). A diagnosis of SSDE was made in any patient with total scores of the BDI-II >12 or CES-D >16 in the absence of any DSM-IV diagnosis of mood disorder according to the MINI. RESULTS: Patients with SSDEs (n = 26) had a worse quality of life than asymptomatic patients (n = 103). This finding was also observed among patients with MDEs only (n = 10), anxiety disorders only (n = 21), or mixed MDEs/anxiety disorders (n = 28). Furthermore, having mixed SSDEs/anxiety disorders yielded a worse quality of life than having only SSDEs. Independent predictors of poor quality of life included having a psychiatric disorder and persistent epileptic seizures in the last 6 months. CONCLUSIONS: Although isolated mood and anxiety disorders, including SSDE, have a comparable negative impact on the quality of life of PWEs; the comorbid occurrence of mood and anxiety disorders yields a worse impact. In addition, seizure freedom in the previous 6 months predicts a better quality of life.
机译：研究的目的：比较焦虑症，重度抑郁发作（MDE）和亚综合征性抑郁发作（SSDEs）对癫痫患者（PWE）生活质量的影响，并确定可预测癫痫患者不良质量的变量生活。方法：通过MINI国际神经精神病学访谈，在188个连续的PWE中建立了根据DSM-IV-TR标准进行的精神病学诊断。患者还完成了Beck抑郁量表II（BDI-II），流行病学研究中心抑郁症（CES-D）以及癫痫89的生活质量（QOLIE-89）。根据MINI，在总分BDI-II> 12或CES-D> 16的所有患者中，如果没有任何DSM-IV诊断为情绪障碍，则诊断为SSDE。结果：SSDEs患者（n = 26）比无症状患者（n = 103）的生活质量较差。在只有MDEs（n = 10），只有焦虑症（n = 21）或混合MDEs /焦虑症（n = 28）的患者中也观察到了这一发现。此外，混合SSDE /焦虑症比仅拥有SSDE的生活质量差。生活质量低下的独立预测因素包括最近6个月内患有精神病和持续性癫痫发作。结论：尽管孤立的情绪和焦虑症（包括SSDE）对PWE的生活质量具有相当的负面影响;情绪和焦虑症并存会产生更严重的影响。此外，前六个月的癫痫发作自由度预示着生活质量的改善。

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