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首页> 外文期刊>Epilepsia: Journal of the International League against Epilepsy >Clinical and neurophysiologic features of active convulsive epilepsy in rural Kenya: a population-based study.
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Clinical and neurophysiologic features of active convulsive epilepsy in rural Kenya: a population-based study.

机译：肯尼亚农村地区活动性惊厥性癫痫的临床和神经生理学特征：一项基于人群的研究。

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PURPOSE: Epilepsy is common in sub-Saharan Africa but is poorly characterized. Most studies are hospital-based, and may not reflect the situation in rural areas with limited access to medical care. We examined people with active convulsive epilepsy (ACE), to determine if the clinical features could help elucidate the causes. METHODS: We conducted a detailed descriptive analysis of 445 people with ACE identified through a community-based survey of 151,408 people in rural Kenya, including the examination of electroencephalograms. RESULTS: Approximately half of the 445 people with ACE were children aged 6 to 18 years. Seizures began in childhood in 78% of those diagnosed. An episode of status epilepticus was recalled by 36% cases, with an episode of status epilepticus precipitated by fever in 26%. Overall 169 had an abnormal electroencephalogram, 29% had focal features, and 34% had epileptiform activity. In the 146 individuals who reported generalized tonic-clonic seizures only, 22% had focal features on their electroencephalogram. Overall 71% of patients with ACE had evidence of focal abnormality, documented by partial onset seizures, focal neurologic deficits, or focal abnormalities on the electroencephalogram. Increased seizure frequency was strongly associated with age and cognitive impairment in all ages and nonattendance at school in children (p < 0.01). DISCUSSION: Children and adolescents bear the brunt of epilepsy in a rural population in Africa. The predominance of focal features and the high proportion of patients with status epilepticus, suggests that much of the epilepsy in this region has identifiable causes, many of which could be prevented.
机译：目的：癫痫病在撒哈拉以南非洲很常见，但特征较差。大多数研究是基于医院的，可能无法反映获得医疗服务有限的农村地区的情况。我们检查了活动性惊厥性癫痫（ACE）患者，以确定其临床特征是否可以帮助阐明原因。方法：我们通过对肯尼亚农村地区151,408人的社区调查，包括脑电图检查，对445名ACE患者进行了详细的描述性分析。结果：445名ACE患者中约有一半是6至18岁的儿童。 78％的确诊为儿童癫痫发作。有36％的病例回忆起癫痫持续状态发作，其中有26％的患者因发烧而引起癫痫持续状态发作。总体169例脑电图异常，29％具局灶性特征，34％具癫痫样活动。在仅报告全身性强直性阵挛性癫痫发作的146个个体中，有22％的脑电图具有局灶性特征。总体上71％的ACE患者有局灶性异常的证据，通过部分发作，癫痫发作，局灶性神经系统缺陷或脑电图上的局灶性异常来证明。癫痫发作频率增加与所有年龄段的年龄和认知障碍以及儿童在校缺勤密切相关（p <0.01）。讨论：非洲农村人口中，儿童和青少年首屈一指。局灶性疾病的主要特征和癫痫持续状态患者的高比例表明，该地区的许多癫痫病都有可识别的原因，许多原因可以预防。

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