Death receptors

Harald Wajant

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Death receptors

机译：死亡受体

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Death receptors {Fas/Apo-l/CD95,TNF-R1 [tumour necrosis factor (TNF) receptor 1],DR3 [death receptor 3],TRAIL-R1 [TNF-related apoptosis-inducing ligand receptor 1],TRAIL-R2,DR6,p75-NGFR [p75-nerve growth factor receptor],EDAR [ectodermal dysplasia receptor]} form a subgroup of the TNF-R superfamily that can induce apoptosis (programmed cell death) via a conserved cytoplasmic signalling module termed the death domain.Although death receptors have been recognized mainly as apoptosis inducers,there is growing evidence that these receptors also fulfil a variety of non-apoptotic functions.This review is focused on the molecular mechanisms of apoptotic and non-apoptotic death receptor signalling in light of the phenotype of mice deficient in the various death receptors.

机译：死亡受体{Fas / Apo-1 / CD95，TNF-R1 [肿瘤坏死因子（TNF）受体1]，DR3 [死亡受体3]，TRAIL-R1 [TNF相关凋亡诱导配体受体1]，TRAIL-R2 ，DR6，p75-NGFR [p75-神经生长因子受体]，EDAR [外胚层发育异常受体]}形成TNF-R超家族的一个亚组，可通过称为死亡域的保守细胞质信号模块诱导凋亡（程序性细胞死亡）。尽管死亡受体主要被认为是凋亡诱导因子，但越来越多的证据表明这些受体还具有多种非凋亡功能。这篇综述着眼于凋亡和非凋亡死亡受体信号转导的分子机制。各种死亡受体不足的小鼠的表型。

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《Essays in Biochemistry》 |2003年第0期|共19页
作者
Harald Wajant;
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正文语种 eng
中图分类生物化学;
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1. Fenretinide-dependent upregulation of death receptors through ASK1 and p38|[alpha]| enhances death receptor ligand-induced cell death in Ewing's sarcoma family of tumours [J] . D E White, S A Burchill British Journal of Cancer . 2010,第9期

机译：通过ASK1和p38 |α|依赖于芬维A胺的死亡受体上调增强Ewing肉瘤家族中死亡受体配体诱导的细胞死亡
2. Synthetic peptides corresponding to ligand-binding region of death receptors, DR5, Fas, and TNFR, specifically inhibit cell death mediated by the death ligands, respectively [J] . Kazumi Kajiwara, Atsuhiro Saito, Shin-ichi Ogata, Biochimica et biophysica acta: BBA: International journal of biochemistry, biophysics and molecular biololgy. Proteins and Proteomics . 2004,第1a2期

机译：对应于死亡受体DR5，Fas和TNFR配体结合区的合成肽分别特异性抑制由死亡配体介导的细胞死亡
3. Regulation of Death Receptor-Induced Apoptosis Induced via CD95/Fas and Other Death Receptors [J] . I. N. Lavrik Molecular Biology . 2011,第1期

机译：通过CD95 / Fas和其他死亡受体诱导死亡受体诱导的细胞凋亡的调控
4. Death receptor-mediated programmed cell death in the liver [C] . P. R. GALLE, S. KANZLER, S. STRAND Falk Symposium . 2000

机译：死亡受体介导的肝脏中的编程细胞死亡
5. Characterization of the interactions of calmodulin with Fas and death receptor-5, and determine the role of calmodulin - death receptor-5 binding in disc formation in breast cancer [D] . Fancy, Romone M. 2013

机译：表征钙调蛋白与Fas和死亡受体5的相互作用，并确定钙调蛋白-死亡受体5结合在乳腺癌椎间盘形成中的作用
6. Fenretinide-dependent upregulation of death receptors through ASK1 and p38α enhances death receptor ligand-induced cell death in Ewings sarcoma family of tumours [O] . D E White, S A Burchill 2010

机译：Fenretinide依赖于ASK1和p38α的死亡受体上调增强了Ewing肉瘤家族中死亡受体配体诱导的细胞死亡
7. Fenretinide-dependent upregulation of death receptors through ASK1 and p38α enhances death receptor ligand-induced cell death in Ewing's sarcoma family of tumours [O] . White, D E, Burchill, S A 2010

机译：Fenretinide依赖于ASK1和p38α的死亡受体上调增强了Ewing肉瘤家族中死亡受体配体诱导的细胞死亡

Death receptors

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