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首页> 外文期刊>Epilepsy currents >Neuronal firing in human epileptic cortex: the ins and outs of synchrony during seizures.
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Neuronal firing in human epileptic cortex: the ins and outs of synchrony during seizures.

机译：人类癫痫皮层的神经元放电：癫痫发作期间的来龙去脉。

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The location and trajectory of seizure activity is of great importance, yet our ability to map such activity remains primitive. Recently, development of multi-electrode arrays for use in humans has provided new levels of temporal and spatial resolution for recording seizures. Here, we show that there is a sharp delineation between areas, showing intense hypersynchronous firing indicative of recruitment to the seizure, and adjacent territories where there is only low-level, unstructured firing. Thus, there is a core territory of recruited neurons and a surrounding "ictal penumbra."The defining feature of the ictal penumbra is the contrast between the large amplitude EEG signals and the low-level firing there. Our human recordings bear striking similarities with animal studies of an inhibitory restraint, indicating they can be readily understood in terms of this mechanism. These findings have important implications for how we localize seizure activity and map its spread.
机译：癫痫发作活动的位置和轨迹非常重要，但是我们绘制此类活动的能力仍然很原始。近来，用于人类的多电极阵列的发展为记录癫痫发作提供了新水平的时间和空间分辨率。在这里，我们表明区域之间存在着清晰的界线，显示出强烈的超同步射击，表明已经招募了癫痫发作者，而邻近地区则只有低水平，无组织的射击。因此，存在一个新征神经元的核心区域和周围的“半影半影”。半影半影的定义特征是大振幅脑电信号与那里的低水平放电之间的对比。我们的人类录音与抑制性抑制动物研究具有惊人的相似性，表明它们很容易理解这种抑制机制。这些发现对我们如何定位癫痫发作活动及其分布图具有重要意义。

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