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首页> 外文期刊>Epidemiology >Air pollution and exacerbation of asthma in African-American children in Los Angeles.
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Air pollution and exacerbation of asthma in African-American children in Los Angeles.

机译：洛杉矶非裔美国人儿童的空气污染和哮喘加重。

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Significant increases in asthma morbidity and mortality in the United States have occurred since the 1970s, particularly among African-Americans. Exposure to various environmental factors, including air pollutants and allergens, has been suggested as a partial explanation of these trends. To examine relations between several air pollutants and asthma exacerbation in African-Americans, we recruited a panel of 138 children in central Los Angeles. We recorded daily data on respiratory symptoms and medication use for 13 weeks and examined these data in conjunction with data on ozone (O3) nitrogen dioxide (NO2), particulate matter (PM10 and PM2.5), meteorological variables, pollens, and molds. Using generalized estimating equations, we found associations between respiratory symptom occurrence and several environmental factors. For example, new episodes of cough were associated with exposure to PM10 (OR = 1.25; 95% CI = 1.12-1.39; interquartile range [IQR] = 17 microg/m3, 24-hour average), PM2.5 (OR = 1.10; 95% CI = 1.03-1.18; IQR = 30 microg/m3, 12-hour average), NO2, and the molds Cladosporium and Alternaria, but not with exposure to O3 or pollen. The factors PM10 and O3 were associated with the use of extra asthma medication. For this population several bioaerosols and air pollutants had effects that may be clinically significant.
机译：自1970年代以来，美国的哮喘发病率和死亡率显着增加，尤其是在非裔美国人中。建议暴露于各种环境因素，包括空气污染物和过敏原，以部分解释这些趋势。为了研究非裔美国人中几种空气污染物与哮喘恶化之间的关系，我们在洛杉矶市中心招募了138名儿童组成的小组。我们记录了13周的每日呼吸道症状和用药数据，并结合臭氧（O3），二氧化氮（NO2），颗粒物（PM10和PM2.5），气象变量，花粉和霉菌的数据进行了检查。使用广义估计方程，我们发现呼吸系统症状的发生与一些环境因素之间的关联。例如，新的咳嗽发作与PM10暴露相关（OR = 1.25; 95％CI = 1.12-1.39;四分位间距[IQR] = 17 microg / m3，平均24小时），PM2.5（OR = 1.10） ; 95％CI = 1.03-1.18; IQR = 30 microg / m3，平均12小时），NO2和霉菌Cladosporium和Alternaria，但不暴露于O3或花粉。 PM10和O3因子与额外哮喘药物的使用相关。对于这种人群，几种生物气溶胶和空气污染物的影响可能在临床上具有重要意义。

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