• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Esophagus >Impact of extracapsular lymph node involvement on tumor progression in esophageal squamous cell carcinoma after neoadjuvant therapy and effects on lymph nodes induced by chemotherapy and chemoradiotherapy
【24h】

Impact of extracapsular lymph node involvement on tumor progression in esophageal squamous cell carcinoma after neoadjuvant therapy and effects on lymph nodes induced by chemotherapy and chemoradiotherapy

机译：新辅助治疗后食管鳞状细胞癌累及囊外淋巴结对肿瘤进展的影响以及化疗和放化疗对淋巴结的影响

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Background Neoadjuvant therapy followed by surgery can improve long-term survival and reduce local recurrence in patients with esophageal squamous cell carcinoma (ESCC). Extracapsular lymph node involvement (ECLNI) reflects tumor progression in gastrointestinal malignancies. The aim of this study was to clarify the correlation between ECLNI and clinical outcome in ESCC following neoadjuvant therapy. Methods A total of 36 patients with ESCC who underwent neoadjuvant therapy followed by surgery were enrolled in this study (CT: n = 16; CRT: n = 20). The correlation between ECLNI and clinicopathological variables was investigated. In addition, we also evaluated whether differences in pathological response existed between primary tumors and metastatic lymph nodes (LNs), and whether chemotherapy (CT) and chemoradiotherapy (CRT) had different effects on LNs. Results Of 36 patients, 22.2 % had detectable ECLNI. ECLNI was significantly correlated with tumor size (>40 mm), LN density (2:20%), advanced stage, lymphatic invasion, non-RO resection, and poor pathological response. Patients with ECLNI had a significantly poorer prognosis than those without ECLNI (P = 0.0040). No differences in pathological response were observed between primary tumors and metastatic LNs for each type of therapy. The median number of dissected LNs was 21, 45, and 14 in the surgery alone (n = 22), CT, and CRT groups, respectively (P < 0.05). More severe morphologic changes in LNs appeared to be induced by CRT than by CT. Conclusion ECLNI was correlated with poor prognosis in patients with ESCC after neoadjuvant therapy. CT and CRT had different effects on LNs.
机译：背景技术新辅助治疗后进行手术可提高食管鳞状细胞癌（ESCC）患者的长期生存率并减少其局部复发。囊外淋巴结受累（ECLNI）反映了胃肠道恶性肿瘤中的肿瘤进展。这项研究的目的是阐明新辅助治疗后ECLNI与ESCC临床结果之间的相关性。方法本研究共纳入36例行新辅助治疗并接受手术的ESCC患者（CT：n = 16; CRT：n = 20）。研究了ECLNI与临床病理变量之间的相关性。此外，我们还评估了原发性肿瘤与转移性淋巴结（LNs）之间是否存在病理反应差异，以及化疗（CT）和放化疗（CRT）对LNs是否有不同的影响。结果在36例患者中，有22.2％的患者可检测到ECLNI。 ECLNI与肿瘤大小（> 40 mm），LN密度（2：20％），晚期，淋巴管浸润，非RO切除和不良的病理反应密切相关。与没有ECLNI的患者相比，有ECLNI的患者的预后明显较差（P = 0.0040）。对于每种疗法，在原发性肿瘤和转移性LNs之间未观察到病理反应的差异。仅手术组（n = 22），CT组和CRT组的解剖LN的中位数分别为21、45和14（P <0.05）。 CRT比CT诱发更严重的LN形态变化。结论ECLNI与新辅助治疗后ESCC患者预后差有关。 CT和CRT对LN的影响不同。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号