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首页> 外文期刊>Esophagus >Tumor blood flow change measured by CT perfusion during chemoradiation therapy (CRT) for monitoring response and predicting survival in patients with esophageal cancer
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Tumor blood flow change measured by CT perfusion during chemoradiation therapy (CRT) for monitoring response and predicting survival in patients with esophageal cancer

机译：食管癌患者在放化疗期间通过CT灌注测量的肿瘤血流变化以监测反应并预测食道癌患者的生存

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Background The purpose of this study is to evaluate whether computed tomography perfusion (CTP) can evaluate the biological change during chemoradiation therapy (CRT) and the survival of patients with esophageal cancer after CRT.Methods Thirty-two consecutive patients (31 men, 1 woman; mean age 65.9 years) with esophageal squamous cell carcinoma underwent CTP before and 2-3 weeks after CRT. The perfusion data were analyzed using software based on the deconvolution method. We investigated the relationship between the changes of CTP parameters during CRT, the response to CRT and outcome. Results This study included 22 clinical responders and 10 non-responders. Post-CRT blood flow (BF) was significantly lower than pre-CRT (P = 0.0003). BF in responders decreased significantly greater than in non-responders (P < 0.0001). Patients whose tumors showed a greater reduction (greater than 15 % reduction) in BF during CRT survived significantly longer than those with lower tumor BF reduction (P = 0.03).Conclusions Substantial BF change may help to evaluate the response to CRT and survival in patients with advanced esophageal squamous cell carcinoma.
机译：背景技术本研究的目的是评估计算机断层扫描（CTP）能否评估化学放疗（CRT）期间的生物学变化以及食管癌患者在CRT后的生存率。方法32例连续患者（31例男性，1例女性） ;平均年龄65.9岁）的食管鳞状细胞癌在CRT之前和之后2-3周接受了CTP。使用基于反卷积方法的软件分析灌注数据。我们调查了CRT期间CTP参数的变化，对CRT的反应和结果之间的关系。结果本研究包括22位临床反应者和10位无反应者。 CRT后的血流量（BF）显着低于CRT前（P = 0.0003）。应答者的BF下降明显大于无应答者（P <0.0001）。肿瘤在CRT期间BF降低程度更大（大于15％降低）的患者的存活时间显着长于BF降低程度较低的患者（P = 0.03）。结论BF的实质性改变可能有助于评估患者对CRT的反应和生存率晚期食管鳞状细胞癌。

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