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Impact of serum biomarkers on esophageal squamous cell carcinoma

机译：血清生物标志物对食管鳞癌的影响

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摘要

Esophageal squamous cell carcinoma (SCC) is frequently associated with a high mortality rate as a result of late diagnosis and/or aggressive behavior. Although multimodal treatment is applied for advanced tumors, many patients suffer from progressive disease and rapid recurrence. Besides various imaging techniques, serum biomarkers should also be useful for early diagnosing and treatment monitoring. A comprehensive review is provided here mainly on advancements of our clinical research in serum biomarkers to diagnose and/or monitor esophageal SCC. First, we focused on conventional secretory type serum markers, SCC-antigen and CYFRA 21-1. Both serum markers are useful to predict high-risk patients to develop recurrent disease. Second, we reviewed the clinicopathological significance of various angiogenic factors, vascular endothelial growth factor, thymidine phosphory-lase, fibroblast growth factor, midkine, and hepatocyte growth factor. These growth factors could be useful biomarkers to predict lymph node and/or distant metastases. Finally, we reviewed advancements of clinical research on autoantibodies against tumor-specific antigens, particularly focused on serum p53 antibody. Because serum antibodies frequently respond to a small volume of tumors, they are useful in early tumor detection and prediction of residual cancer cells. Serum biomarkers may be a useful tool in the management of esophageal SCC.
机译：食管鳞状细胞癌（SCC）经常由于晚期诊断和/或攻击性行为而导致高死亡率。尽管多模式治疗被用于晚期肿瘤，但是许多患者患有进行性疾病和快速复发。除各种成像技术外，血清生物标志物也应用于早期诊断和治疗监测。本文主要针对我们在血清生物标志物诊断和/或监测食管鳞癌中的临床研究进展提供了全面的综述。首先，我们关注常规的分泌型血清标志物，SCC抗原和CYFRA 21-1。两种血清标志物均可用于预测高危患者发展为复发性疾病。其次，我们回顾了各种血管生成因子，血管内皮生长因子，胸苷磷酸酶，成纤维细胞生长因子，midkine和肝细胞生长因子的临床病理学意义。这些生长因子可能是预测淋巴结和/或远处转移的有用生物标志物。最后，我们综述了针对肿瘤特异性抗原的自身抗体的临床研究进展，特别是针对血清p53抗体。由于血清抗体经常对少量肿瘤产生反应，因此可用于早期肿瘤检测和预测残留癌细胞。血清生物标志物可能是食管食管鳞癌治疗中的有用工具。

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