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首页> 外文期刊>Esophagus >Clinical significance of peritumoral mast cells in esophageal squamous cell carcinoma with neoadjuvant chemoradiotherapy
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Clinical significance of peritumoral mast cells in esophageal squamous cell carcinoma with neoadjuvant chemoradiotherapy

机译：食管鳞癌新辅助放化疗对肿瘤周围肥大细胞的临床意义

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Background Neoadjuvant chemoradiotherapy (CRT) followed by surgery is the standard approach for locally advanced esophageal cancer. Recently, the microenviron-ment (including the host immune response) after conventional chemo- and/or radiotherapy has been highlighted. The aim of this preliminary study was to evaluate peritumoral mast cells (MCs) in esophageal squamous cell carcinoma (ESCC) after neoadjuvant CRT. Methods We obtained a total of twenty specimens from patients with ESCC who underwent neoadjuvant CRT (30-40 Gy; 5-fluorouracil plus cisplatin) followed by surgery. We evaluated the expression of tryptase by MCs, Foxp3 by regulatory T cells, CD8 by cytotoxic T cells, and micro vessel density (MVD) using immunohistochemistry. We investigated the correlation between the sizes of these marker-positive cell populations surrounding residual tumor nests, MVD and CRP, and clinical outcome. Results Patients with a low number of peritumoral MCs more frequently had lymphatic invasion (P = 0.0191). There was no significant correlation among the sizes of the marker-positive cell populations. We observed a significant negative correlation between the number of MCs and preoperative CRP levels (P = 0.009). Low numbers of peritumoral MCs, high MVD, and a preoperative C-reactive protein of >0.5 mg/dL were significantly associated with poor overall survival (MCs: P = 0.0239; MVD: P = 0.0317; CRP: P = 0.0395). Conclusion Our results suggest that peritumoral MCs may be associated with prognosis in patients with ESCC after neoadjuvant CRT.
机译：背景技术新辅助放化疗（CRT）然后进行手术是局部晚期食管癌的标准方法。最近，常规化学疗法和/或放射疗法后的微环境（包括宿主免疫反应）已得到强调。这项初步研究的目的是评估新辅助CRT后食管鳞状细胞癌（ESCC）的肿瘤周围肥大细胞（MCs）。方法我们从经新辅助CRT（30-40 Gy; 5-氟尿嘧啶加顺铂）行手术的ESCC患者中获得了总共20份标本。我们使用免疫组化方法评估了胰蛋白酶的胰蛋白酶表达，调节性T细胞的Foxp3表达，细胞毒性T细胞的CD8表达以及微血管密度（MVD）。我们调查了残留肿瘤巢周围的这些标志物阳性细胞群的大小，MVD和CRP与临床结果之间的相关性。结果肿瘤周围MC较少的患者更常发生淋巴管浸润（P = 0.0191）。标记阳性细胞群的大小之间没有显着相关性。我们观察到MC数量与术前CRP水平之间显着负相关（P = 0.009）。肿瘤周围MC数量少，MVD高和术前C反应蛋白> 0.5 mg / dL与不良的总生存率显着相关（MCs：P = 0.0239; MVD：P = 0.0317; CRP：P = 0.0395）。结论我们的结果表明，新辅助CRT后ESCC患者的肿瘤周围MC可能与预后有关。

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