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首页> 外文期刊>Bioelectromagnetics. >Effects of 50 Hz sinusoidal magnetic fields on Hsp27, Hsp70, Hsp90 expression in porcine aortic endothelial cells (PAEC).
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Effects of 50 Hz sinusoidal magnetic fields on Hsp27, Hsp70, Hsp90 expression in porcine aortic endothelial cells (PAEC).

机译：50 Hz正弦磁场对猪主动脉内皮细胞（PAEC）中Hsp27，Hsp70，Hsp90表达的影响。

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摘要

The aim of the present study was to investigate the influence of 50 Hz sinusoidal magnetic field on Hsp27, Hsp70, and Hsp90 expression in a model of primary culture of porcine aortic endothelial cells (PAEC). We took into consideration the Hsp profile in terms of mRNA expression, protein expression and protein localization inside the cells. The choice of the cell system was motivated by the involvement of the endothelial cells in the onset of many diseases; moreover, only few reports describe the effects of extremely low frequency magnetic fields (ELF-MFs) on such cells. ELF-MF exposure induced an increase in the mRNA levels of the three proteins, which was statistically significant for Hsp70. On the contrary, we did not observe any influence on Hsp27, Hsp70, and Hsp90 protein levels. Analysis in situ by immunofluorescence revealed that ELF-MF exposure affected the cellular distribution of Hsp27; in particular a partial relocalization in the nucleus was observed.
机译：本研究的目的是研究猪主动脉内皮细胞（PAEC）的原代培养模型中50 Hz正弦磁场对Hsp27，Hsp70和Hsp90表达的影响。我们在细胞内mRNA表达，蛋白表达和蛋白定位方面考虑了Hsp谱。细胞系统的选择是由内皮细胞参与许多疾病的发作所激发的。此外，只有极少数的报告描述了极低频磁场（ELF-MF）对此类电池的影响。 ELF-MF暴露导致这三种蛋白质的mRNA水平增加，这对Hsp70具有统计学意义。相反，我们没有观察到对Hsp27，Hsp70和Hsp90蛋白水平的任何影响。通过免疫荧光原位分析表明，ELF-MF暴露会影响Hsp27的细胞分布。特别是观察到细胞核中有部分重新定位。

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