...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>European journal of neurology: the official journal of the European Federation of Neurological Societies >Cytotoxic T lymphocyte associated antigen-4 exon 1 A/G polymorphism in Iranian patients with multiple sclerosis.
【24h】

Cytotoxic T lymphocyte associated antigen-4 exon 1 A/G polymorphism in Iranian patients with multiple sclerosis.

机译：伊朗多发性硬化症患者的细胞毒性T淋巴细胞相关抗原4外显子1 A / G多态性。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

BACKGROUND: Cytotoxic T lymphocyte antigen-4 (CTLA-4) is a T-cell surface receptor of activated T cells. MATERIAL AND METHODS: We studied 100 Iranian patients with clinically definite multiple sclerosis (MS) and 100 ethnic, sex- and age-matched controls. CTLA-4 exon 1 A/G polymorphism was compared amongst patients and controls. RESULTS: There was no statistically significant difference in the allelic [odds ratio (OR): 1.19, confidence interval (CI) 95%: 0.76-1.85, P = 0.4] and genotypes (OR: 1.60, CI 95%: 0.911-2.824, P = 0.102) distribution amongst patients and controls. Also gender, course and progression index did not reveal any statistically significant differences in allele and genotype distribution of A/G polymorphism. CONCLUSION: As a non-European patient population, our results are consistent with the major previous studies showing no significant associations between CTLA4 exon 1 polymorphism and neither MS nor any of its subtypes.
机译：背景：细胞毒性T淋巴细胞抗原4（CTLA-4）是活化T细胞的T细胞表面受体。材料与方法：我们研究了100例临床明确的多发性硬化症（MS）伊朗患者和100例种族，性别和年龄相匹配的对照。在患者和对照中比较了CTLA-4外显子1 A / G多态性。结果：等位基因[比值比（OR）：1.19，置信区间（CI）95％：0.76-1.85，P = 0.4]和基因型（OR：1.60，CI 95％：0.911-2.824）均无统计学差异。 ，P = 0.102）在患者和对照组之间的分布。性别，病程和进展指数也未显示出A / G多态性的等位基因和基因型分布在统计学上有显着差异。结论：作为非欧洲患者人群，我们的结果与先前的主要研究一致，后者显示CTLA4外显子1多态性与MS或其任何亚型之间均无显着关联。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号