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首页> 外文期刊>European journal of neurology: the official journal of the European Federation of Neurological Societies >Voxel-based morphometry in patients with obsessive-compulsive behaviors in behavioral variant frontotemporal dementia
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Voxel-based morphometry in patients with obsessive-compulsive behaviors in behavioral variant frontotemporal dementia

机译：行为变异额颞痴呆患者强迫行为的基于体素的形态计量学

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Background and purpose: Obsessions and compulsive (OC) behaviors are a frequent feature of behavioral variant frontotemporal dementia (bvFTD), but their structural correlates have not been definitively established. Methods: Patients with bvFTD presenting to the Mayo Clinic Alzheimer's Disease Research Center were recruited. Each patient's caregiver was given the Yale-Brown Obsessive-Compulsive scale (YBOCS) to document the type and presence of OC behaviors and to rate their severity. All subjects underwent standardized magnetic resonance imaging (MRI) that was evaluated using voxel-based morphometry (VBM). Seventeen patients with bvFTD were recruited, and 11 were included in the study and compared with 11 age- and gender-matched controls. Six were excluded for lack of MRI at the time of survey or a pre-existing neurodegenerative condition. Results: Nine of the 11 reported OC behaviors, with the most frequent compulsions being checking, hoarding, ordering/arranging, repeating rituals, and cleaning. In the VBM analysis, total YBOCS score correlated with gray matter loss in the bilateral globus pallidus, left putamen, and in the lateral temporal lobe, particularly the left middle and inferior temporal gyri (P<0.001 uncorrected for multiple comparisons). Conclusions: Obsessive-compulsive behaviors were frequent among these patients. The correlation with basal ganglia atrophy may point to involvement of frontal subcortical neuronal networks. Left lateral temporal lobe volume loss probably reflects the number of MAPT mutation patients included but also provides additional data implicating temporal lobe involvement in OC behaviors.
机译：背景与目的：强迫症和强迫行为是行为变异额颞叶痴呆（bvFTD）的常见特征，但尚未明确确定它们的结构相关性。方法：招募到梅奥诊所阿尔茨海默氏病研究中心的bvFTD患者。为每位患者的护理人员提供耶鲁-布朗强迫症量表（YBOCS），以记录OC行为的类型和存在并评估其严重程度。所有受试者均接受了标准化的磁共振成像（MRI），该成像使用基于体素的形态计量学（VBM）进行了评估。招募了17名bvFTD患者，并将11名患者纳入研究，并与11名年龄和性别匹配的对照进行了比较。由于在调查时没有MRI或已有神经退行性疾病而被排除在外。结果：在11种报告的OC行为中，有9种是强迫行为，最常见的强迫行为是检查，ho积，整理/安排，重复仪式和清洁。在VBM分析中，总的YBOCS得分与双侧苍白球，左侧核壳和外侧颞叶，尤其是左侧中颞下回回的灰质损失相关（P <0.001，未经多次比较校正）。结论：这些患者中强迫性行为频繁。与基底神经节萎缩的相关性可能表明额叶皮层下神经元网络的参与。左侧颞叶体积的丢失可能反映了所包括的MAPT突变患者的数量，但也提供了暗示颞叶参与OC行为的其他数据。

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