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首页> 外文期刊>European journal of neurology: the official journal of the European Federation of Neurological Societies >Causes of death in patients with multiple sclerosis and matched referent subjects: A population-based cohort study
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Causes of death in patients with multiple sclerosis and matched referent subjects: A population-based cohort study

机译：多发性硬化症患者和相关参考对象的死亡原因：一项基于人群的队列研究

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Background and purpose: Multiple sclerosis (MS) has been associated with increased mortality rates. However, influence of lifestyle parameters remains unknown, and inconsistencies exist regarding findings for causes of death. Methods: We conducted a population-based cohort study using the General Practice Research Database, Hospital Episode Statistics, and national death certificates (January 2001 through March 2008). To each patient with MS (n=1270), up to six referent subjects without MS were matched by age, gender, and practice. Cox proportional hazards models were used to estimate mortality rate ratios (HRs). Results: Patients with MS had a 3.5-fold increased mortality rate for all-cause mortality, compared with referent subjects (HR 3.51, 95% CI 2.63-4.69). The rate further increased amongst current smokers (HR 6.72, 95% CI 4.16-10.87) (but not in ex-smokers) and subjects with a body mass index of 20kg/m 2 (HR 6.67, 95% CI 3.50-12.73). The HR was highest for infectious/respiratory-related deaths (HR 7.69, 95% CI 4.92-12.02) and was significantly increased for deaths related to cardiovascular diseases (2.4-fold) and cancer (1.9-fold), but not for accidents and suicide related deaths. Conclusion: British patients with MS have a 3.5-fold increased mortality rate compared with the general population. Smoking and respiratory diseases are major (potentially preventable) factors related to increased mortality rate amongst patients with MS.
机译：背景与目的：多发性硬化症（MS）与死亡率增加相关。然而，生活方式参数的影响仍然未知，并且关于死亡原因的发现存在不一致之处。方法：我们使用“全科医学研究数据库”，“医院病情统计”和国家死亡证明（2001年1月至2008年3月）进行了基于人群的队列研究。对于每例MS患者（n = 1270），按年龄，性别和习俗匹配多达6名无MS的参考对象。使用Cox比例风险模型估算死亡率比（HRs）。结果：与参照对象相比，MS患者的全因死亡率提高了3.5倍（HR 3.51，95％CI 2.63-4.69）。在目前的吸烟者中（HR 6.72，95％CI 4.16-10.87）（但在前吸烟者中则没有）和体重指数<20kg / m 2的受试者（HR 6.67，95％CI 3.50-12.73），该比例进一步增加。对于感染/呼吸相关的死亡，HR最高（HR 7.69，95％CI 4.92-12.02），与心血管疾病相关的死亡（2.4倍）和癌症的死亡（1.9倍）显着增加，但对于意外事件和与自杀有关的死亡。结论：英国MS患者的死亡率比普通人群高3.5倍。吸烟和呼吸系统疾病是与MS患者死亡率增加相关的主要因素（可能是可预防的）。

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