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首页> 外文期刊>European journal of neurology: the official journal of the European Federation of Neurological Societies >Late-onset myasthenia not on the increase: A nationwide register study in Denmark, 1996-2009
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Late-onset myasthenia not on the increase: A nationwide register study in Denmark, 1996-2009

机译：迟发性肌无力没有增加：1996-2009年在丹麦进行的一项全国性登记研究

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Background: An increase in late-onset myasthenia gravis (MG) has been reported. There are few large population-based studies over longer periods of time reflecting recent developments in MG incidence. Methods: We identified a nationwide cohort of patients with incident myasthenia in Denmark in 1996-2009. We used a validated algorithm to track subjects based on a combination of diagnosis and prescription (pyridostigmine) data from nationwide registers. Patients with myasthenia were classified into early onset (<50 years old) and late onset (50+ years). We calculated incidence rates (IRs) and corresponding 95% confidence intervals. Results: We identified 693 patients (362 women) with incident MG in the study period corresponding to an IR of 9.2 per million person-years (8.5-9.9). Overall, 207 (29.9%) were classified as early-onset and 486 (70.1%) as late-onset MG. Women predominated in the early-onset group (70.5%), but not in the late-onset group (44.4%). The incidence rate of early-onset MG was 4.2 (3.6-4.8) and late-onset MG 18.9 (17.3-20.7) per million person-years and it did not vary over time in the study period (P-values for trend 0.54 and 0.15, respectively). Conclusion: Late-onset MG comprised a large proportion of all incident cases in Denmark, was more common in men than women, and occurred with a stable incidence in the 14-year study period. Therefore, we speculate whether previous reports of a rise in late-onset MG reflect a non-biological phenomenon, that is, a gradual improvement in the diagnosis of MG in this age group in previous years.
机译：背景：据报道，迟发性重症肌无力（MG）增加。很少有大型的基于人群的长期研究反映出MG发病率的最新发展。方法：我们确定了1996-2009年在丹麦发生的全国性重症肌无力患者队列。我们使用了一种经过验证的算法，根据来自全国性注册机构的诊断和处方（吡tig斯的明）数据的组合来跟踪受试者。重症肌无力患者分为早期发作（<50岁）和晚期发作（50+岁）。我们计算了发生率（IR）和相应的95％置信区间。结果：在研究期间，我们确定了693名MG患者（362名女性），对应的IR为每百万人年9.2（8.5-9.9）。总体而言，207例（29.9％）被归为早发性MG，486例（70.1％）被归为迟发性MG。女性在早发组中占主导地位（70.5％），但在晚发组中则不占优势（44.4％）。每百万人年早发性MG的发生率是4.2（3.6-4.8）和晚发性MG 18.9（17.3-20.7），并且在研究期间没有随时间变化（趋势P值为0.54和0.5）。分别为0.15）。结论：迟发性MG在丹麦所有发病病例中占很大比例，男性多于女性，并且在14年的研究期内发病率稳定。因此，我们推测以前报道的迟发性MG升高是否反映了一种非生物现象，即前几年该年龄组MG的诊断逐渐改善。

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