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首页> 外文期刊>European journal of neurology: the official journal of the European Federation of Neurological Societies >Low serum uric acid concentration in Parkinson's disease in southern Spain
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Low serum uric acid concentration in Parkinson's disease in southern Spain

机译：西班牙南部帕金森氏病患者血清尿酸浓度低

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Background and purpose: Uric acid (UA) is thought to have an antioxidant effect on the central nervous system and may also prevent cerebral damage induced by oxidative stress. Our study aimed to investigate whether patients with Parkinson's disease (PD) had lower serum UA concentrations than controls and whether UA concentration was related to clinical parameters of the disease. Methods: We included 161 patients with PD and 178 controls from southern Spain. UA concentration was compared between these two groups. Clinical parameters including severity of the disease were related to serum UA. Results: Patients with PD showed statistically significant lower serum UA concentrations than controls. Serum UA concentration was lower in patients with PD in severe stages (4 and 5) than in those in moderate stage (2) according to the modified Hoehn and Yahr scale. Other clinical parameters were not related to serum UA concentration, except for levodopa equivalent daily dose that was associated with lower serum UA concentration in men. Conclusions: Our study produced consistent findings that UA might have a protective effect against PD and could influence its clinical progression.
机译：背景和目的：尿酸（UA）被认为对中枢神经系统具有抗氧化作用，还可以预防氧化应激引起的脑损伤。我们的研究旨在调查帕金森病（PD）患者的血清UA浓度是否低于对照组，以及UA浓度是否与疾病的临床参数有关。方法：我们包括来自西班牙南部的161例PD患者和178例对照。比较这两组的UA浓度。临床参数包括疾病的严重程度与血清UA有关。结果：PD患者的血清UA浓度在统计学上低于对照组。根据改良的Hoehn和Yahr量表，重症PD患者（4和5）的血清UA浓度低于中度（2）患者。其他临床参数与血清UA浓度无关，除了左旋多巴等效日剂量与男性较低的血清UA浓度有关。结论：我们的研究得出一致的发现，UA可能对PD具有保护作用，并可能影响其临床进展。

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