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首页> 外文期刊>European journal of neurology: the official journal of the European Federation of Neurological Societies >Neurological and neurophysiological examinations on workers with chronic poisoning by 2,3,7,8-TCDD: follow-up 35 years after exposure.
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Neurological and neurophysiological examinations on workers with chronic poisoning by 2,3,7,8-TCDD: follow-up 35 years after exposure.

机译：2,3,7,8-TCDD对患有慢性中毒的工人进行神经和神经生理学检查：暴露后35年的随访。

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摘要

Between 1965 and 1968, about 350 workers were accidentally exposed to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in a chemical plant, which was producing herbicides based on the trichlorophenoxyacetic acid. About 80 workers developed signs of poisoning. The estimated mean concentration of TCDD at the time of exposure was about 5000 pg/g of plasma fat. Only 15 subjects from the original cohort remained available for the recent follow-up in 2004. All were men, mean age 60 years. The mean current TCDD plasma concentration was 128 pg/g. Neurological examination revealed some CNS impairment in eight subjects. Signs of polyneuropathy were found in nine subjects, confirmed by NCV studies in three cases. Electroencephalography was abnormal in three cases; Visual-evoked potential in five cases. Acquired dyschromatopsia was detected in six patients. SPECT showed focal reduction of perfusion in various brain locations in all but one patient. Two neuropsychological variables and the frequency of abnormal neurophysiological tests in individual patients correlated with TCDD plasma level. The findings support the hypothesis that TCDD can damage the nervous system. In addition to a direct neurotoxic effect of TCDD, changes secondary to vasculopathy should be considered, in the pathophysiology of the damage, because of the high frequency of lipid metabolism disorders and their complications.
机译：在1965年至1968年之间，约有350名工人在化工厂中偶然接触2,3,7,8-四氯二苯并-对-二恶英（TCDD），该工厂生产基于三氯苯氧乙酸的除草剂。大约80名工人出现中毒迹象。暴露时TCDD的估计平均浓度约为5000 pg / g血浆脂肪。 2004年的最新随访中，仅保留了来自原始队列的15名受试者。所有受试者均为男性，平均年龄60岁。当前的平均TCDD血浆浓度为128 pg / g。神经系统检查发现八名受试者中有一些中枢神经系统损伤。 NCV研究证实3例患者中有9例患有多发性神经病。脑电图异常3例。视觉诱发电位五例。在六名患者中检测到获得性色盲。 SPECT显示，除一名患者外，所有患者大脑各部位的灌注均出现局灶性减少。个体患者的两个神经心理学变量和异常神经生理学检查的频率与TCDD血浆水平相关。这些发现支持了TCDD可以损害神经系统的假说。除了TCDD的直接神经毒性作用外，由于脂质代谢紊乱及其并发症的发生率高，在损害的病理生理中还应考虑继发于血管病变的变化。

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