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首页> 外文期刊>European journal of nutrition >An atherogenic diet decreases liver FXR gene expression and causes severe hepatic steatosis and hepatic cholesterol accumulation: effect of endurance training.
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An atherogenic diet decreases liver FXR gene expression and causes severe hepatic steatosis and hepatic cholesterol accumulation: effect of endurance training.

机译：有动脉粥样硬化的饮食会降低肝脏FXR基因的表达，并导致严重的肝脂肪变性和肝胆固醇蓄积：耐力训练的效果。

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Purpose: The aim of this study was to determine the effects of an atherogenic diet (AD; 40% lipid, 1.25% cholesterol, kcal) on triglyceride (TAG) and cholesterol accumulation in liver and on gene expression of liver X receptor (LXR) and farnesoid X receptor (FXR) and their target genes and to observe if these responses are affected by endurance training. Methods: Sprague-Dawley rats (n=32) were divided into two groups and randomly assigned to an AD or a standard diet (SD) for 7 weeks. Half of the rats in each group were assigned to an exercise training program for 5 days/week. Results: The AD resulted in a large (P<0.01) accumulation in liver TAG (4x) along with elevated liver and plasma cholesterol without any gain in peripheral fat mass. The liver TAG and cholesterol accumulations were associated with an important reduction (P<0.01; 60%) in FXR, but no change in LXR transcripts. Accompanying the reduction in FXR gene expression, we found an increase (P<0.001) in SREBP-1c and a decrease (P<0.01) in MTP mRNAs suggesting an increased lipogenesis and a reduced VLDL production, respectively. The AD was also associated with lower HMG-CoA-r, squalene synthase, and ABCG8 transcripts (P<0.001). In the intestine, exercise training resulted in higher NPC1L1, ABCG5, and ABCG8 in SD-fed animals, while all these increases were suppressed under the AD feeding. Conclusions: It is concluded that dietary cholesterol favors liver TAG and cholesterol accumulations associated with an important reduction in FXR transcripts.
机译：目的：本研究旨在确定动脉粥样化饮食（AD; 40％脂质，1.25％胆固醇，kcal）对肝脏中甘油三酸酯（TAG）和胆固醇蓄积以及肝X受体（LXR）基因表达的影响和法尼醇X受体（FXR）及其靶基因，并观察这些反应是否受耐力训练的影响。方法：将Sprague-Dawley大鼠（n = 32）分为两组，并随机分配给AD或标准饮食（SD），持续7周。每组中有一半的大鼠被分配进行为期5天/周的运动训练计划。结果：AD导致肝脏TAG（4x）大量积累（P <0.01），同时肝脏和血浆胆固醇升高，而外周脂肪量没有任何增加。肝脏TAG和胆固醇的积累与FXR的显着降低有关（P <0.01; 60％），但LXR转录本没有变化。伴随着FXR基因表达的减少，我们发现SREBP-1c的增加（P <0.001）和MTP mRNA的减少（P <0.01）分别表明脂肪形成增加和VLDL产生减少。 AD还与较低的HMG-CoA-r，角鲨烯合酶和ABCG8转录物相关（P <0.001）。在肠道中，运动训练导致SD喂养动物的NPC1L1，ABCG5和ABCG8升高，而所有这些增加在AD喂养下均被抑制。结论：结论是饮食中的胆固醇有利于肝脏TAG和与FXR转录物显着减少有关的胆固醇积聚。

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