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首页> 外文期刊>European journal of nutrition >Dietary, lifestyle, and genetic determinants of vitamin D status: a cross-sectional analysis from the European Prospective Investigation into Cancer and Nutrition (EPIC)-Germany study.
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Dietary, lifestyle, and genetic determinants of vitamin D status: a cross-sectional analysis from the European Prospective Investigation into Cancer and Nutrition (EPIC)-Germany study.

机译：饮食，生活方式和遗传因素决定了维生素D的状况：来自德国癌症与营养前瞻性研究（EPIC）的横断面分析。

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Purpose: Considerable variation in 25-hydroxyvitamin D (25(OH)D) in populations worldwide that seems to be independent of latitude has been reported. Therefore, we aimed to assess vitamin D status of a mid-aged German general population and to identify its dietary, lifestyle, anthropometric, and genetic determinants. Methods: 25(OH)D concentrations were measured by LC-MS/MS in plasma samples of a random subcohort of the German arm of the European Prospective Investigation into Cancer and Nutrition (EPIC) comprising 2,100 subjects aged 35-65 years. Associations between potential predictors and 25(OH)D were assessed by linear regression models. Results 32.8% of the variance in 25(OH)D was explained by a multivariable regression model, with season being the by far strongest predictor (semi-partial R2: 14.6%). Sex, waist circumference, leisure time physical activity, smoking, polymorphisms in the GC, CYP2R1, and DHCR7 genes, supplement use, exogenous hormone use, alcohol consumption, egg consumption, and fish consumption were significantly associated with 25(OH)D concentrations as well. However, none of these factors explained >2.3% of the variance in 25(OH)D. Conclusion: Even with a comprehensive set of genetic, anthropometric, dietary, and lifestyle correlates, not more than 32.8% of the variation in 25(OH)D could be explained in the EPIC-Germany study, implying that vitamin D prediction scores may not provide an appropriate proxy for measured 25(OH)D. Food intake was only a weak predictor of 25(OH)D concentrations, while a strong seasonal fluctuation in 25(OH)D was shown.
机译：目的：据报道，全球人口中25-羟基维生素D（25（OH）D）的变化似乎与纬度无关。因此，我们旨在评估德国中年人的维生素D状况，并确定其饮食，生活方式，人体测量学和遗传因素。方法：通过LC-MS / MS在欧洲癌症与营养前瞻性调查（EPIC）德国分部的一个随机分组的血浆样本中测量了25（OH）D浓度，该样本包括2,100名年龄在35-65岁之间的受试者。潜在的预测因素和25（OH）D之间的关联通过线性回归模型进行评估。结果通过多元回归模型可以解释25（OH）D中32.8％的方差，其中季节是迄今为止最强的预测指标（半部分R 2 ：14.6％）。性别，腰围，休闲时间的体育活动，吸烟，GC，CYP2R1和DHCR7基因的多态性，补充剂的使用，外源激素的使用，酒精的摄入，蛋的摄入和鱼的摄入与25（OH）D浓度显着相关，因为好。但是，这些因素都不能解释25（OH）D的变异> 2.3％。结论：即使有一套全面的遗传，人体测量学，饮食和生活方式相关性，EPIC-Germany的研究也无法解释25（OH）D变异中不超过32.8％，这意味着维生素D预测分数可能不提供适当的25（OH）D替代指标。食物摄入量只是25（OH）D浓度的弱预测指标，而25（OH）D的季节性波动却很强。

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