...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>European journal of neurology: the official journal of the European Federation of Neurological Societies >Aspirin versus anticoagulation in intra- and extracranial vertebral artery dissection
【24h】

Aspirin versus anticoagulation in intra- and extracranial vertebral artery dissection

机译：阿司匹林与抗凝治疗颅内和颅外动脉

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Background and purpose: To evaluate the incidence and predictors of ischaemic recurrent stroke and the adverse events of antithrombotic therapy in patients with first intra- or extracranial vertebral artery dissection (VAD) who were treated with aspirin or oral anticoagulation (OA). Methods: A 21-year database of consecutive patients with confirmed diagnoses of VAD (n = 110, 63% men; mean age 37.9 ± 8.5 years) without intracerebral hemorrhage and who were treated with aspirin or OA were analyzed retrospectively. In all cases, the admission diagnosis was ischaemic stroke. Three groups were defined according to the site of the dissection: (i) extracranial, (ii) intracranial, and (iii) intra-/extracranial. Clinical follow-up was obtained by neurologic examination. Outcome measures were (i) recurrent ischaemic events (ischaemic stroke or transient ischaemic attack) and (ii) intra- and extracranial major bleeding. Results: No difference in age, smoking, or hypertension was found between patients treated with OA (n = 49) and those treated with aspirin (n = 50). Extracranial artery dissection (49%) had preponderance over intracranial (27%) or intra-/extracranial (23%) location. During the follow-up, recurrent ischaemic events were rare (one case). There were no bleeding complications. The treatment that was used did not influence the functional outcome or recanalization. A good functional outcome (modified Rankin score ≤ 2) was observed in 82 patients. Conclusions: Although this was a non-randomized study, our data suggest that the frequency of recurrent ischaemic stroke in patients with intra- or extracranial VAD is low and most likely independent of the type of antithrombotic treatment.
机译：背景与目的：评价接受阿司匹林或口服抗凝（OA）治疗的首次颅内或颅外椎动脉夹层（VAD）患者的缺血性中风复发的发生率和预测因素以及抗栓治疗的不良事件。方法：回顾性分析21年来连续确诊为VAD的患者（n = 110，63％男性;平均年龄37.9±8.5岁），无脑出血且接受阿司匹林或OA治疗的患者。在所有情况下，入院诊断均为缺血性中风。根据解剖部位分为三组：（i）颅外，（ii）颅内和（iii）颅内/颅外。通过神经系统检查获得临床随访。结果指标为（i）复发性缺血事件（缺血性中风或短暂性脑缺血发作）和（ii）颅内和颅外大出血。结果：在接受OA治疗的患者（n = 49）和接受阿司匹林治疗的患者（n = 50）之间，年龄，吸烟或高血压无差异。颅外动脉清扫术（49％）比颅内（27％）或颅内/颅外（23％）占优势。在随访期间，复发性缺血事件很少见（1例）。没有出血并发症。使用的治疗方法不影响功能预后或再通。在82例患者中观察到良好的功能结局（改良的Rankin评分≤2）。结论：尽管这是一项非随机研究，但我们的数据表明，颅内或颅外VAD患者复发性缺血性卒中的发生率较低，并且很可能与抗栓治疗的类型无关。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号