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首页> 外文期刊>European journal of neurology: the official journal of the European Federation of Neurological Societies >Inhibition of peripheral blood natural killer cell cytotoxicity in patients with myasthenia gravis treated with plasmapheresis.
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Inhibition of peripheral blood natural killer cell cytotoxicity in patients with myasthenia gravis treated with plasmapheresis.

机译：用血浆置换术治疗重症肌无力患者抑制外周血自然杀伤细胞的细胞毒性。

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摘要

BACKGROUND AND PURPOSE: Myasthenia gravis (MG) is an autoimmune disorder that may involve natural killer (NK) cells. Although NK cells are part of the innate immune system, they also influence adaptive immune responses. Double-filtration plasmapheresis (DFP) is an effective therapy for MG crisis. Thus, we examined the effects of DFP on the cytotoxicity of NK cells. METHODS: A total of 20 patients with MG and 16 healthy controls were recruited for the study. Ficoll-Paque-isolated peripheral blood mononuclear cells (PBMCs) and K562 cells were used as the effector and target cells, respectively. NK cell cytotoxicity was analyzed using flow cytometry immediately before and after DFP and upon course completion. RESULTS: Double-filtration plasmapheresis treatment decreased significantly the NK cell cytotoxicity in patients with MG, especially in good responders, those who were positive for acetylcholine receptor (AChR) antibodies, and those receiving immunosuppressants. CONCLUSIONS: The decrease in NK cell cytotoxicity after DFP and the decline of AChR antibody titer were observed in good responders indicating that this could benefit patients with MG.
机译：背景与目的：重症肌无力（MG）是一种自身免疫性疾病，可能涉及自然杀伤（NK）细胞。尽管NK细胞是先天免疫系统的一部分，但它们也会影响适应性免疫反应。双滤血浆置换术（DFP）是治疗MG危机的有效方法。因此，我们检查了DFP对NK细胞的细胞毒性的影响。方法：共招募了20名MG患者和16名健康对照者。 Ficoll-Paque分离的外周血单个核细胞（PBMC）和K562细胞分别用作效应细胞和靶细胞。在DFP之前和之后以及疗程结束后立即使用流式细胞仪分析NK细胞的细胞毒性。结果：双滤血浆置换治疗可显着降低MG患者的NK细胞细胞毒性，尤其是对反应良好的患者，乙酰胆碱受体（AChR）抗体阳性的患者和接受免疫抑制剂的患者。结论：在良好反应者中观察到DFP后NK细胞的细胞毒性下降和AChR抗体滴度下降，表明这可以使MG患者受益。

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