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首页> 外文期刊>European journal of neurology: the official journal of the European Federation of Neurological Societies >Taste disorders in myasthenia gravis: A multicenter cooperative study
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Taste disorders in myasthenia gravis: A multicenter cooperative study

机译：重症肌无力的味觉障碍：多中心合作研究

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摘要

Background and purpose: The purpose of the present study was to investigate the prevalence and clinical characteristics of taste disorders in patients with myasthenia gravis (MG). Methods: We studied 371 Japanese patients with MG (127 men and 244 women; mean age, 56.6±16.9years) consecutively evaluated between May and September 2010 in six neurological centers comprising the East Japan MG Study Group. Ninety-three patients (25%) had thymoma. We interviewed all patients to determine whether they had taste disorders during the clinical course of MG and then further evaluated the patients with MG, who reported having taste disorders, using a questionnaire. Results: Taste disorders were observed in 16 (4.3%) of the 371 patients with MG. We concluded that taste disorders in 2.4% of patients with MG excluding other factors were associated with MG itself. All patients had thymoma with seropositivity for anti-acetylcholine receptor antibodies. Thymoma tended to be advanced, and four patients with Masaoka stage IVa required radiation therapy or chemotherapy. Five patients noticed taste disorders 2-3months before the onset of MG. Sweet taste loss was more common than salty, bitter, and sour taste loss. Conclusions: This was the first systematic survey of taste disorders in patients with MG by a multicenter study. Taste disorders were more common in the present sample of patients with MG than in the general population.
机译：背景与目的：本研究的目的是调查重症肌无力（MG）患者味觉障碍的患病率和临床特征。方法：我们在2010年5月至9月间，对包括东日本MG研究组在内的六个神经病学中心连续评估了371名日本MG患者（127名男性和244名女性;平均年龄56.6±16.9岁）。 93例（25％）患有胸腺瘤。我们采访了所有患者，以确定他们在MG的临床过程中是否患有味觉障碍，然后使用问卷调查表进一步评估了患有味觉障碍的MG患者。结果：371名MG患者中有16名（4.3％）出现了味觉障碍。我们得出的结论是，排除其他因素，2.4％的MG患者的味觉障碍与MG本身有关。所有患者的胸腺瘤均具有抗乙酰胆碱受体抗体的血清阳性。胸腺瘤倾向于晚期，四名Masaoka IVa期患者需要放疗或化疗。五名患者在MG发作前2-3个月注意到味觉障碍。甜味的损失比咸味，苦味和酸味的损失更为普遍。结论：这是一项多中心研究首次对MG患者的味觉障碍进行系统的调查。在MG患者的当前样本中，味觉障碍比普通人群更为普遍。

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