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首页> 外文期刊>European journal of neurology: the official journal of the European Federation of Neurological Societies >Prevention of post-stroke cognitive decline: A review focusing on lifestyle interventions
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Prevention of post-stroke cognitive decline: A review focusing on lifestyle interventions

机译:预防中风后认知功能减退:以生活方式干预为重点的综述

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Background and purpose: Despite a high prevalence of post-stroke cognitive impairment, therapeutic possibilities are still limited. Stroke and dementia share the same cluster of modifiable risk factors. Thus, lifestyle interventions and strict adherence to medication may not only decrease the risk of recurrent stroke but also the risk of post-stroke cognitive decline. Methods: We performed a systematic literature search for randomized clinical trials (RCTs) targeting modifiable risk factors for the prevention of cognitive decline following stroke. Results: We identified 25 non-pharmacological interventions and eight multiple risk factor interventions in stroke patients using cognition as outcome measure. None of the published trials investigated interventions aimed at the prevention of post-stroke cognitive decline. However, a number of ongoing trials aim at risk factor reduction and include measures on cognition. Conclusion: Evidence for risk factor modification for the prevention of cognitive decline after stroke is scarce and comes mainly from observational studies. There is a need for more RCTs targeting the prevention of post-stroke dementia using lifestyle interventions and a multiple risk factor approach.
机译:背景与目的:尽管中风后认知功能障碍的患病率很高,但治疗可能性仍然有限。中风和痴呆症具有可改变的危险因素。因此,生活方式干预和严格遵守药物治疗不仅可以降低中风复发的风险,还可以降低中风后认知功能下降的风险。方法:我们进行了系统的文献搜索,针对可改变的危险因素的随机临床试验(RCT),以预防中风后认知功能下降。结果:我们使用认知作为结果衡量指标,对中风患者确定了25种非药物干预措施和8种多危险因素干预措施。没有公开的试验研究过旨在预防中风后认知功能下降的干预措施。但是,许多正在进行的试验旨在降低危险因素,并包括认知措施。结论:预防卒中后认知功能下降的危险因素修饰证据很少,主要来自观察性研究。需要使用生活方式干预措施和多危险因素方法来针对预防卒中后痴呆的更多RCT。

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