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首页> 外文期刊>European journal of neurology: the official journal of the European Federation of Neurological Societies >The prevalence of neuromyelitis optica in South East Wales
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The prevalence of neuromyelitis optica in South East Wales

机译：威尔士东南部视神经脊髓炎的患病率

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Background and purpose: Neuromyeltis optica (NMO) is a neuroinflammatory disorder considered rare in Caucasian populations. However, accurate population-based epidemiological data for NMO and NMO spectrum disorder (NMO-SD) from Western populations employing validated diagnostic criteria remain limited. We sought therefore to estimate the prevalence and clinical features of NMO in a north European Caucasian population in South East Wales. Methods: Patients were identified by a comprehensive, multistage ascertainment strategy employing a regional neuroinflammatory disease register, hospital diagnostic databases personal physician referrals and regional requests for anti-aquaporin-4 antibodies (anti-AQP4). Results: Fourteen Caucasian patients (11 patients with NMO and three with NMO-SD) were identified in a population of 712572 (19.6/million; 95% CIs: 12.2-29.7). There was an excess of females (female:male 12:2), 11/14 were anti-AQP4 positive and 5/14 had disease onset under the age of 20years. Conclusion: This study suggests that NMO and related spectrum disorders are at least as frequent in Northern European populations as in non-Caucasian populations and that the demographic profile of prevalent patients differs from clinic-based cohorts.
机译：背景与目的：视神经脊髓炎（NMO）是一种在白种人中罕见的神经炎性疾病。但是，采用有效的诊断标准从西方人群获得的有关NMO和NMO谱系疾病（NMO-SD）的准确的基于人群的流行病学数据仍然有限。因此，我们试图评估NMO在东南威尔士的北欧高加索人群中的患病率和临床特征。方法：通过全面，多阶段的确定策略，使用区域神经炎性疾病登记簿，医院诊断数据库，个人医生推荐以及抗水通道蛋白4抗体（anti-AQP4）区域要求，对患者进行鉴定。结果：在712572的人群中确定了14例白人患者（11例NMO患者和3例NMO-SD患者）（百万分之19.6; 95％CI：12.2-29.7）。女性过多（女性：男性12：2），11/14的抗AQP4阳性和5/14的疾病发病年龄在20岁以下。结论：这项研究表明，北欧人群中的NMO和相关频谱异常至少与非高加索人群中的频率相同，而且普遍患者的人口统计学特征与基于临床的人群不同。

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