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首页> 外文期刊>European journal of nutrition >The relative bioavailability in humans of elemental iron powders for use in food fortification.
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The relative bioavailability in humans of elemental iron powders for use in food fortification.

机译：用于食品强化的元​​素铁粉在人体中的相对生物利用度。

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Background: Bioavailability data in humans of elemental iron powders is limited, although elemental iron is a common form of iron when used as a fortificant. Aim: The relative bioavailability (RBV) of seven elemental iron powders, five commercially available and two developmental, are evaluated. In addition, one commercial electrolytic iron powder given with ascorbic acid (AA) was examined. Methods: Based on a validated method, this double-blinded, randomized, cross-over study included three groups of male blood donors (n=3*16) who received rolls fortified with different elemental iron powders or ferrous sulfate (FeSO4) nine weeks apart. Blood samples were drawn every hour for six hours. RBV was obtained by comparing the increase in serum iron concentration induced by the elemental iron with the increase induced by FeSO4. Results: All elemental iron powders studied were significantly less well absorbed compared to FeSO4. The electrolytic iron given with 50-mg AA was well absorbed as FeSO4 (molar ratio=1:6, AA:Fe). The mean RBVs of the iron powders were: electrolytic (A-131, RBV=0.65); electrolytic (electrolytic, RBV=0.59); carbonyl (ferronyl, RBV=0.58); H-reduced (AC-325, RBV=0.56); H-reduced (Hi-Sol, RBV=0.50); carbonyl (CF, RBV=0.37); reduced (Atomet 95SP, RBV=0.36). The reduced iron was distinguished by having significantly lower RBV (0.36), although no significant overall ranking was possible. Conclusion: Based on a validated method this double-blinded, cross-over study in humans showed that the evaluated elemental iron powders currently available for commercial use are significantly less well absorbed compared with FeSO4. The reduced iron powder was absorbed to a lower extent compared with the other iron powders and only 36% compared with FeSO4. AA seems to improve the bioavailability of elemental iron eventhough a rather low molar ratio is used, suggesting its applicability as a co-fortificant..
机译：背景：元素铁粉在人体中的生物利用度数据有限，尽管元素铁在用作强化剂时是铁的一种常见形式。目的：评估了七种元素铁粉的相对生物利用度（RBV），其中五种为市售品，而两种为开发品。另外，还研究了一种添加有抗坏血酸（AA）的市售电解铁粉。方法：基于一种经过验证的方法，该双盲，随机，交叉研究包括三组男性献血者（n = 3 * 16），他们接受了用不同元素铁粉或硫酸亚铁（FeSO4）强化的面包卷，为期九周。分开。每小时抽血一次，持续六个小时。通过比较元素铁引起的血清铁浓度增加与FeSO4引起的血清铁浓度增加获得RBV。结果：与FeSO4相比，所有研究的元素铁粉的吸收率均显着降低。给予50 mg AA的电解铁被FeSO4吸收好（摩尔比= 1：6，AA：Fe）。铁粉的平均RBV为：电解（A-131，RBV = 0.65）;电解的（电解的，RBV = 0.59）;羰基（亚铁酰基，RBV = 0.58）; H降低（AC-325，RBV = 0.56）;降低H（Hi-Sol，RBV = 0.50）;羰基（CF，RBV = 0.37）;降低（Atomet 95SP，RBV = 0.36）。还原铁的特征在于RBV（0.36）明显较低，尽管总体排名不可能。结论：基于一种经过验证的方法，这项对人体的双盲交叉研究表明，与FeSO4相比，目前可用于商业用途的经评估的元素铁粉吸收性明显差。与其他铁粉相比，还原铁粉的吸收程度较低，与FeSO4相比仅吸收36％。尽管使用了相当低的摩尔比，AA似乎可以改善元素铁的生物利用度，表明其可作为辅助剂使用。

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