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首页> 外文期刊>European journal of clinical microbiology and infectious diseases: Official publication of the European Society of Clinical Microbiology >Prevalence of the ica operon and insertion sequence IS256 among Staphylococcus epidermidis prosthetic joint infection isolates.
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Prevalence of the ica operon and insertion sequence IS256 among Staphylococcus epidermidis prosthetic joint infection isolates.

机译：表皮葡萄球菌假体关节感染分离株中ica操纵子和插入序列IS256的患病率。

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摘要

Joint replacement surgery has improved the quality of life for hundreds of thousands of patients. However, the infection of a joint implant is an important and serious complication, though the prevalence is low. Staphylococcus epidermidis is the most important pathogen involved in foreign-body infections. S. epidermidis is also a commensal that comprises a substantial part of the normal skin flora of humans. The possibility to demonstrate potential specific virulence markers may facilitate the interpretation of the bacteriological findings, as well as the clinical decision. The prevalence of the ica locus and insertion sequence IS256 by using polymerase chain reaction (PCR) among 32 clinical S. epidermidis isolates from prosthetic joint infections (PJIs) and 24 commensal isolates from nares and skin was investigated. Sixteen (50%) of the 32 PJI isolates harbored the ica operon compared with one-third of the commensal isolates obtained from the samples of the skin and nares of healthy individuals. The IS256 was demonstrated in 26 (81%) out of 32 PJI isolates. By contrast, IS256 was found in one of 24 commensal isolates. In conclusion, IS256 may be superior to the ica operon as a marker of the invasive capacity of S. epidermidis, since it was found in most of the PJI isolates, but rarely among commensals.
机译：关节置换手术改善了成千上万患者的生活质量。然而，尽管患病率很低，但关节植入物的感染是重要且严重的并发症。表皮葡萄球菌是涉及异物感染的最重要病原体。表皮葡萄球菌也是占人类正常皮肤菌群很大一部分的表象。证明潜在的特定毒力标记的可能性可能有助于解释细菌学发现以及临床决策。通过聚合酶链反应（PCR），对32例来自假体关节感染（PJI）的临床表皮葡萄球菌分离株和24株来自鼻孔和皮肤的共生分离株的ica基因座和插入序列IS256的患病率进行了调查。 32种PJI分离株中有16种（50％）带有ica操纵子，而从健康个体的皮肤和鼻孔样本中获得的共生分离株中有三分之一。在32种PJI分离物中的26种（81％）中证实了IS256。相比之下，在24种常见分离株之一中发现了IS256。总之，IS256作为表皮葡萄球菌侵袭能力的标志物可能优于ica操纵子，因为在大多数PJI分离物中都发现了IS256，但很少见到。

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