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首页> 外文期刊>European journal of anaesthesiology >Association of N-terminal pro-brain natriuretic peptide and cardiac troponin T with in-hospital cardiac events in elderly patients undergoing coronary artery surgery.
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Association of N-terminal pro-brain natriuretic peptide and cardiac troponin T with in-hospital cardiac events in elderly patients undergoing coronary artery surgery.

机译：老年冠状动脉手术患者的N末端脑钠肽和心肌肌钙蛋白T与院内心脏事件的关系。

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BACKGROUND AND OBJECTIVES: Despite evidence of their prognostic power for non-surgical patients, the value of perioperative natriuretic peptides and cardiac troponins as markers of cardiac events is incompletely defined. This study sought to examine whether perioperative N-terminal pro-brain natriuretic peptide (NT-proBNP) and cardiac troponin T (cTnT) levels could be used for the prediction of in-hospital cardiac events in elderly patients undergoing elective coronary artery bypass grafting. METHODS: Ninety-eight elderly patients (>75 yr) undergoing elective coronary artery bypass grafting with cardiopulmonary bypass were enrolled and followed up for 121 and 0.66 1 for NT-proBNP and cTnT (sensitivity, specificity, positive predictive value and negative predictive value of 84.3%, 89.4%, 78.9% and 92.4%, and 93.7%, 74.2%, 63.8% and 96.1%, respectively) at 24 h after surgery to be associated with in-hospital cardiac events. An elevation of both biomarkers above these threshold values was independently associated with individual postoperative complications (odds ratio, 18.9; 95%, CI, 2.3-106.1). CONCLUSIONS: In elderly patients undergoing elective coronary artery bypass grafting surgery, high values of NT-proBNP and cTnT measured 24 h after the end of surgery were independently associated with in-hospital cardiac events.
机译：背景与目的：尽管有证据表明其可用于非手术患者，但围手术期利钠肽和心肌肌钙蛋白作为心脏事件标志物的价值尚未完全确定。这项研究试图检查围手术期N末端脑钠素前体肽（NT-proBNP）和心肌肌钙蛋白T（cTnT）水平是否可用于预测接受冠状动脉搭桥术的老年患者的院内心脏事件。方法：选择了98例年龄> 75岁的行冠状动脉旁路搭桥术并接受体外循环的老年患者，对NT-proBNP和cTnT分别随访121和0.66±1（敏感性，特异性，阳性预测值和阴性预测值）。院内心脏事件发生在术后24 h分别为84.3％，89.4％，78.9％和92.4％，93.7％，74.2％，63.8％和96.1％。两种生物标志物高于这些阈值的升高均与个体术后并发症相关（赔率，18.9; 95％，CI，2.3-106.1）。结论：在接受择期冠状动脉搭桥术的老年患者中，手术结束后24小时测得的高NT-proBNP和cTnT值与院内心脏事件独立相关。

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