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首页> 外文期刊>European journal of clinical nutrition >The relation between single/double or repeated tea catechin ingestions and plasma antioxidant activity in humans.
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The relation between single/double or repeated tea catechin ingestions and plasma antioxidant activity in humans.

机译：人体摄入单/双或重复茶儿茶素与血浆抗氧化活性之间的关系。

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OBJECTIVE: The purpose of this study was to investigate the effects of single/double or repeated intake of a normal amount of tea catechin on plasma catechin concentrations and antioxidant activity in young women. DESIGN: First, after an overnight fast, five healthy subjects were given water or single/double dose(s) of tea polyphenol extract (164 mg tea catechins containing 61% epigallocatechin gallate in 190 ml water). Blood samples were taken before and 30, 60 and 180 min after the ingestion. Second, 16 healthy subjects ingested the tea polyphenol extract three times a day at mealtimes for 7 days followed by withdrawal of tea polyphenol extract for 7 days. Blood samples were taken before and after ingestion, and 7 days after the withdrawal of tea catechin. Subjects were prohibited from drinking any beverages containing polyphenols or antioxidant supplements during the study period. Catechin and other antioxidant concentrations in the plasma were measured, and changes in antioxidant activity were evaluated by ferric reducing ability of plasma assay. RESULTS:: Single/double ingestion of tea polyphenol extract did not cause an increase in the antioxidant activity. There was no also change in antioxidant activity after the ingestion of tea polyphenol extract for 7 days. Plasma-free epigallocatechin gallate concentration remained at the pre-study level; however, the plasma FRAP value decreased significantly at 7 days after the withdrawal of tea polyphenol extract. Decreases in endogenous antioxidants in the plasma, including vitamin C and bilirubin, were also observed 7 days after withdrawal of tea polyphenol. CONCLUSIONS: The results suggest that continuous daily intake of tea catechins affects the concentrations of endogenous antioxidants in the plasma and has the potential to maintain total antioxidant activity. doi:10.1038/sj.ejcn.1601471
机译：目的：本研究的目的是调查单次/两次或重复摄入正常量的茶儿茶素对年轻女性血浆儿茶素浓度和抗氧化活性的影响。设计：首先，在过夜禁食后，给五名健康受试者喝水或单/双剂量茶多酚提取物（164毫克茶儿茶素，在190毫升水中含有61％的表没食子儿茶素没食子酸酯）。在摄入之前以及摄入后30、60和180分钟采集血样。其次，16名健康受试者每天在进餐时间三次摄入茶多酚提取物，共7天，然后停药7天。摄入前后，抽取茶儿茶素后7天采集血样。在研究期间，受试者不得饮用任何含有多酚或抗氧化剂补充剂的饮料。测量血浆中儿茶素和其他抗氧化剂的浓度，并通过血浆中铁的还原能力评估抗氧化活性的变化。结果：单次/多次摄入茶多酚提取物并没有增加抗氧化活性。茶多酚提取物摄入7天后抗氧化活性也没有变化。无血浆表没食子儿茶素没食子酸酯浓度保持在研究前水平。然而，撤回茶多酚提取物后第7天血浆FRAP值显着下降。茶多酚戒断后7天，血浆中的内源性抗氧化剂（包括维生素C和胆红素）也下降。结论：结果表明，每天连续摄入茶儿茶素会影响血浆中内源性抗氧化剂的浓度，并有可能维持总的抗氧化剂活性。 doi：10.1038 / sj.ejcn.1601471

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