• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>European journal of clinical nutrition >A comparison of the effect of advice to eat either '5-a-day' fruit and vegetables or folic acid-fortified foods on plasma folate and homocysteine.
【24h】

A comparison of the effect of advice to eat either '5-a-day' fruit and vegetables or folic acid-fortified foods on plasma folate and homocysteine.

机译：建议吃“每天五天”的水果和蔬菜或叶酸强化食品对血浆叶酸和高半胱氨酸的影响的比较。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

OBJECTIVE: To assess and compare the effects of natural folate (100 micro g) with those of folic acid from fortified sources (100 micro g/day) on plasma folate and homocysteine. DESIGN: Randomized controlled trial (parallel groups). SETTING: Men and women living in South Wales, UK. SUBJECTS: A total of 135 healthy individuals recruited from the local workforce and blood donor sessions. All subjects possessed the 'wild-type' CC genotype for C677T polymorphism in methylenetetrahydrofolate reductase (MTHFR). INTERVENTIONS: Subjects underwent one of the following dietary interventions for 4 months: (1) fortified diet-usual diet plus 100 microg/day folic acid from fortified foods; (2) natural folate diet-usual diet plus 100 microg/day folate from natural sources; (3) control-usual diet. RESULTS: The fortified group increased reported intake of folic acid from fortified foods compared to other groups (P<0.001) achieving an extra 98 microg/day (95% CI 88-108). The natural folate group increased reported intake of natural source folates compared with the other two groups (P<0.001), but achieved a mean increase of only 50 microg/day (95% CI 34-66). Plasma folate increased (P<0.01) by a similar amount in both intervention groups compared to controls (fortified group 2.97, 95% CI 0.8-5.1; natural group 2.76, 95% CI 0.6-4.9. Plasma homocysteine, vitamins B(6) and B(12) were not significantly changed. CONCLUSIONS: Subjects achieved increases in folate intake using fortified foods more easily than by folate-rich foods, however both sources increased plasma folate by a similar amount. These levels of intake were insufficient to reduce homocysteine concentrations in MTHFR CC homozygotes, but may be more effective in other genotypes.
机译：目的：评估和比较天然叶酸（100微克）与强化来源的叶酸（100微克/天）对血浆叶酸和高半胱氨酸的影响。设计：随机对照试验（平行组）。地点：居住在英国南威尔士州的男女。受试者：从当地劳动力和献血者会议招募的总共135名健康个体。所有受试者在亚甲基四氢叶酸还原酶（MTHFR）中均具有C677T多态性的“野生型” CC基因型。干预措施：受试者接受以下一种饮食干预，为期4个月：（1）强化饮食-日常饮食加强化食品中每天100微克/日的叶酸; （2）天然叶酸饮食-通常饮食加上每天从自然来源摄取100微克叶酸; （3）控制饮食。结果：与其他组相比，强化组报告的强化食品中叶酸的摄入量增加（P <0.001），每天增加98微克（95％CI 88-108）。与其他两组相比，天然叶酸组增加了报告的天然叶酸摄入量（P <0.001），但平均增加仅为50微克/天（95％CI 34-66）。与对照组相比，两个干预组的血浆叶酸增加（P <0.01）量相似（加强组2.97，95％CI 0.8-5.1;天然组2.76，95％CI 0.6-4.9。血浆高半胱氨酸，维生素B（6）结论：B。（12）和B（12）没有显着变化。结论：与富含叶酸的食物相比，使用强化食物使受试者的叶酸摄入增加更为容易，但是两种来源的血浆叶酸含量增加量相似，这些摄入量不足以减少高半胱氨酸。在MTHFR CC纯合子中浓度较高，但在其他基因型中可能更有效。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号