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首页> 外文期刊>European journal of clinical nutrition >Enhancement of natural immune function by dietary consumption of Bifidobacterium lactis (HN019).
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Enhancement of natural immune function by dietary consumption of Bifidobacterium lactis (HN019).

机译：通过饮食上食用双歧杆菌（HN019）增强自然免疫功能。

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摘要

OBJECTIVE: To determine the effects of dietary consumption of Bifidobacterium lactis (strain HN019, DR10TM) on natural immunity. DESIGN: A randomized, double blind, placebo-controlled clinical trial. SETTING: Janeway Medical Centre, Memorial University, St Johns, Newfoundland. SUBJECTS: Twenty-five healthy elderly volunteers (median age 69 y; range 60-83 y). INTERVENTIONS: Twelve control subjects consumed 180 ml low-fat/low-lactose milk twice daily for a period of 6 weeks; 13 test subjects consumed milk supplemented with 1.5x1011 colony-forming units of B. lactis twice daily. Indices of natural immunity, including interferon production, phagocytic capacity and phagocyte-mediated bactericidal activity, were determined via peripheral blood at 0, 3, 6 and 12 weeks post-trial commencement. RESULTS: Subjects who consumed milk containing B. lactis for 6 weeks produced significantly enhanced levels of interferon-alpha, upon stimulation of their peripheral blood mononuclear cells in culture, in comparison to the placebo control group who received milk alone. There were also significant increases in polymorphonuclear cell phagocytic capacity among test group subjects, following consumption of milk supplemented with B. lactis, while individuals who consumed B. lactis-supplemented milk or milk alone showed enhanced phagocyte-mediated bactericidal activity. CONCLUSIONS: The results demonstrate that dietary consumption of B. lactis HN019 can enhance natural immunity in healthy elderly subjects, and that a relatively short-term dietary regime (6 weeks) is sufficient to impart measurable improvements in immunity that may offer significant health benefits to consumers. SPONSORS: Financial support for this project was provided by the New Zealand Dairy Board.
机译：目的：确定饮食中乳酸双歧杆菌（HN019，DR10TM菌株）对自然免疫的影响。设计：一项随机，双盲，安慰剂对照的临床试验。地点：纽芬兰圣约翰斯纪念大学珍妮威医疗中心。受试者：25名健康的老年志愿者（中位年龄69岁;范围60-83岁）。干预措施：十二个对照组受试者每天两次服用180毫升低脂/低乳糖牛奶，持续6周。 13位测试对象每天两次补充1.5x1011乳酸菌集落形成单位的牛奶。在审判开始后0、3、6和12周，通过外周血测定自然免疫的指标，包括干扰素产生，吞噬能力和吞噬细胞介导的杀菌活性。结果：与仅接受牛奶的安慰剂对照组相比，饮用含有乳酸杆菌的牛奶6周的受试者在刺激其外周血单个核细胞后，其产生的干扰素-α水平显着提高。食用牛奶补充乳酸杆菌后，测试组受试者的多形核细胞吞噬能力也显着增加，而食用补充乳酸杆菌或单独添加牛奶的个体则显示出吞噬细胞介导的杀菌活性增强。结论：结果表明，饮食中食用乳杆菌BHN019可以增强健康的老年受试者的自然免疫力，相对短期的饮食方式（6周）足以使免疫力得到可测量的改善，可能对健康产生显着的健康益处。消费者。赞助者：新西兰乳业委员会为该项目提供了财政支持。

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