First in man study of EP217609, a new long-acting, neutralisable parenteral antithrombotic with a dual mechanism of action

Gueret Pierre; Combe S.; Krezel C.; Fuseau E.; van Giersbergen P. L. M.; Petitou M.; Neuhart E.

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First in man study of EP217609, a new long-acting, neutralisable parenteral antithrombotic with a dual mechanism of action

机译：EP217609的首次人体研究，它是一种具有双重作用机制的新型长效，可中和的肠胃外抗栓药

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EP217609 is a parenteral antithrombotic compound combining in one molecule an indirect anti-factor Xa inhibitor, a direct thrombin active site inhibitor and a biotin moiety.

机译：EP217609是一种肠胃外抗血栓形成化合物，在一个分子中结合了间接抗因子Xa抑制剂，直接凝血酶活性位点抑制剂和生物素部分。

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来源
《European journal of clinical pharmacology》 |2016年第9期|共10页
作者
Gueret Pierre; Combe S.; Krezel C.; Fuseau E.; van Giersbergen P. L. M.; Petitou M.; Neuhart E.;
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正文语种 eng
中图分类药理学;
关键词
EP217609; Healthy subjects; Dual thrombin and indirect Xa inhibition; First in man; Pharmacokinetics and pharmacodynamics;

机译：EP217609;健康受试者;双重凝血酶和间接Xa抑制;人为研究;药代动力学和药效学;

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1. First in man study of EP217609, a new long-acting, neutralisable parenteral antithrombotic with a dual mechanism of action [J] . Gueret Pierre, Combe S., Krezel C., European journal of clinical pharmacology . 2016,第9期

机译：EP217609的首次人体研究，它是一种具有双重作用机制的新型长效，可中和的肠胃外抗栓药
2. EP217609, a neutralisable dual-action FIIa/FXa anticoagulant, with antithrombotic effects in arterial thrombosis [J] . Alame Ghina, Mangin Pierre H., Freund Monique, Thrombosis and Haemostasis: Journal of the International Society on Thrombosis and Haemostasis . 2015,第2期

机译：EP217609，一种可中和的双重作用FIIa / FXa抗凝剂，在动脉血栓形成中具有抗血栓形成作用
3. DFT/B3LYP study of the substituent effect on the reaction enthalpies of the individual steps of single electron transfer–proton transfer and sequential proton loss electron transfer mechanisms of chroman derivatives antioxidant action [J] . Najafi Meysam, Mood Kaveh Haghighi, Zahedi Mansour, Computational & theoretical chemistry . 2011,第1a3期

机译：DFT / B3LYP研究取代基对单电子转移-质子转移和相继质子损失电子转移各步反应焓的苯并二氢吡喃衍生物抗氧化作用的机理
4. Enteral versus Parenteral Nutrition: Alterations in Mechanisms of Function in Mucosal Host Defenses [C] . Nicholas A. Meyer, Kenneth A. Kudsk Nestlé Nutrition Workshop . 2003

机译：肠内与肠外营养：粘膜主机防御功能的改变
5. A DUAL STUDY, PART I: 3-AZABICYCLO (3.2.1.) OCTANE DERIVATIVES AS POTENTIAL THERAPEUTIC AGENTS. PART II: STUDIES ON THE MECHANISM OF THE MANNICH REACTION. [D] . POTTI, NARAYANAN DASAN. 1966

机译：双重研究，第一部分：3-氮杂双环（3.2.1。）辛烷衍生物作为潜在的治疗剂。第二部分：曼尼希反应机理的研究。
6. Platelet dysfunction induced by parenteral carbenicillin and ticarcillin. Studies of the dose-response relationship and mechanism of action in dogs. [O] . G. J. Johnson, G. H. Rao, J. G. White 1978

机译：胃肠外羧苄青霉素和替卡西林引起的血小板功能障碍。犬的剂量反应关系和作用机理的研究。
7. A Preliminary Study of the Effects of Repeated Massage on Hypothalamic–Pituitary–Adrenal and Immune Function in Healthy Individuals: A Study of Mechanisms of Action and Dosage [O] . Mark H. Rapaport, Pamela Schettler, Catherine Bresee 2012

机译：重复按摩对健康个体下丘脑 - 垂体 - 肾上腺和免疫功能的初步研究：作用和剂量机制研究

First in man study of EP217609, a new long-acting, neutralisable parenteral antithrombotic with a dual mechanism of action

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