...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>European journal of paediatric neurology: EJPN : official journal of the European Paediatric Neurology Society >Thyroid dysfunction associated with increased low-density lipoprotein cholesterol in epileptic children treated with carbamazepine monotherapy: A causal relationship?
【24h】

Thyroid dysfunction associated with increased low-density lipoprotein cholesterol in epileptic children treated with carbamazepine monotherapy: A causal relationship?

机译：卡马西平单药治疗的癫痫儿童的甲状腺功能障碍与低密度脂蛋白胆固醇升高相关：是因果关系？

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

OBJECTIVE: Lipid abnormalities and thyroid dysfunction have been reported in patients treated with antiepileptic drugs. The aim of this study was to evaluate prospectively the association between thyroid and lipid profile in children treated with carbamazepine (CBZ) monotherapy. MATERIALS AND METHODS: Thyroid function was evaluated in 18 epileptic children, previously reported with CBZ-induced changes in serum lipid profile, before and at 6, 12 and 24 months of CBZ monotherapy. RESULTS: All children had normal thyroid function before the initiation of CBZ treatment. During CBZ therapy thyroid dysfunction, with increased thyrotropin (TSH) and decreased thyroxine (T4), free thyroxine (FT4) and triiodothyronine (T3) was found, while, significant association was revealed between serum low-density lipoprotein cholesterol (LDL-C) and TSH levels at 6 (r=0.469; p=0.043) and 12 (r=0.730; p=0.001) months of treatment. CONCLUSION: Lipid abnormalities may be associated with thyroid hormone disturbance in children treated with CBZ monotherapy. Since thyroid dysfunction and hypercholesterolemia are both associated with a higher atherosclerotic risk special attention and further studies are needed in epileptic patients treated with CBZ monotherapy.
机译：目的：已报道抗癫痫药物治疗的患者存在脂质异常和甲状腺功能异常。这项研究的目的是前瞻性评估接受卡马西平（CBZ）单药治疗的儿童中甲状腺与血脂状况之间的关联。材料与方法：在CBZ单药治疗前，6、12和24个月时以及之前CBZ诱导的血脂变化的18例癫痫患儿中评估了甲状腺功能。结果：所有儿童在开始CBZ治疗之前甲状腺功能正常。在CBZ治疗期间，甲状腺功能异常，甲状腺素（TSH）升高，甲状腺素（T4）降低，游离甲状腺素（FT4）和三碘甲状腺素（T3）被发现，而血清低密度脂蛋白胆固醇（LDL-C）之间存在显着相关性。治疗6个月（r = 0.469; p = 0.043）和12个月（r = 0.730; p = 0.001）的TSH水平。结论：CBZ单药治疗儿童脂质异常可能与甲状腺激素紊乱有关。由于甲状腺功能低下和高胆固醇血症都与较高的动脉粥样硬化风险相关，因此应特别注意，需要进一步研究以CBZ单药治疗的癫痫患者。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号