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首页> 外文期刊>European journal of paediatric neurology: EJPN : official journal of the European Paediatric Neurology Society >Risk factors for postencephalitic epilepsy in children: A hospital-based study in Taiwan.
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Risk factors for postencephalitic epilepsy in children: A hospital-based study in Taiwan.

机译：儿童脑炎后癫痫的危险因素：台湾的一家医院研究。

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摘要

To identify clinical, neurophysiological and neuroradiological features in acute encephalitis with predictive value for postencephalitic epilepsy (PEE) in children, a retrospective cohort study by following up 0-17-year-old children with the diagnosis of acute encephalitis was done. Total 330 children were enrolled. Of these, 54 (16.4%) developed epilepsy with a mean follow-up period of 6+/-4.6 years, and 79.6% had the diagnosis of epilepsy within six months after encephalitis. Significant risk factors for PEE include the presence of recurrent seizures, status epilepticus, severe disturbance of consciousness, the existence of focal neurological sign, and the presence of neurological deterioration during hospitalization. Patients with abnormal electroencephalogram, including focal (P<0.05), or profound cerebral dysfunction (P<0.001), and focal cortical abnormalities in neuroimaging (P<0.01), also have higher incidence of epilepsy. Furthermore, children with refractory status epilepticus at presentation also significantly increased the possibility of intractable PEE (P<0.01). We concluded that PEE is not a rare complication of acute encephalitis. Children with refractory status epilepticus or poor control of seizures are more likely to have intractable PEE.
机译：为了确定急性脑炎的临床，神经生理学和神经放射学特征对儿童脑炎后癫痫（PEE）具有预测价值，通过对0-17岁儿童进行诊断为急性脑炎的回顾性队列研究。共有330名儿童入学。其中54例（16.4％）发展为癫痫病，平均随访期为6 +/- 4.6年，而79.6％的患者在脑炎后六个月内被诊断为癫痫病。 PEE的重要危险因素包括反复发作，癫痫持续状态，意识严重障碍，局灶性神经系统症状的存在以及住院期间神经系统恶化的情况。脑电图异常的患者，包括局灶性（P <0.05）或严重的脑功能障碍（P <0.001），以及神经影像学的局灶性皮质异常（P <0.01），也有较高的癫痫发生率。此外，表现为难治性癫痫持续状态的儿童也显着增加了顽固性PEE的可能性（P <0.01）。我们得出的结论是，PEE不是急性脑炎的罕见并发症。患有难治性癫痫状态或癫痫发作控制不良的儿童更有可能患有顽固性PEE。

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