Methylphenidate improves reading performance in children with attention deficit hyperactivity disorder and comorbid dyslexia: an unblinded clinical trial.

Keulers EH; Hendriksen JG; Feron FJ; Wassenberg R; Wuisman-Frerker MG; Jolles J; Vles JS

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Methylphenidate improves reading performance in children with attention deficit hyperactivity disorder and comorbid dyslexia: an unblinded clinical trial.

机译：哌醋甲酯可改善患有注意力缺陷多动障碍和合并症的阅读障碍儿童的阅读能力：一项无盲临床试验。

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Attention Deficit Hyperactivity Disorder (ADHD) and dyslexia are frequently co-occurring disorders. Although methylphenidate (MPH) is the primary treatment for ADHD, the effect on reading in children with these comorbid problems is not yet known. This study was an unblinded clinical trial to evaluate the reading performance before and after treatment with MPH. Reading performance was compared with General Linear Model repeated measures between three groups: (1) an experimental group of children with both ADHD and dyslexia (N = 24), (2) a control group of children with ADHD (N = 9) and (3) a control group of children with dyslexia (N = 10). MPH improved reading performance significantly stronger in the experimental group than in the control groups; the number of correctly read words increased to a larger extent. In conclusion, MPH proved to be an aid in the reading process of children with ADHD and comorbid dyslexia by improving the learning conditions, but MPH cannot cure the reading disorder. Future research should study the effect of MPH on reading in a double-blind clinical trial.

机译：注意缺陷多动障碍（ADHD）和诵读困难症是经常并发的疾病。尽管哌醋甲酯（MPH）是ADHD的主要治疗方法，但尚不清楚这些合并症患者对阅读的影响。这项研究是一项无盲临床试验，旨在评估MPH治疗前后的阅读表现。将阅读表现与三组之间的通用线性模型重复测量进行比较：（1）实验组患有ADHD和阅读障碍的儿童（N = 24），（2）对照组患有ADHD的儿童（N = 9）和（ 3）患有阅读障碍的儿童对照组（N = 10）。实验组的MPH改善阅读性能明显强于对照组。正确阅读的单词数量在很大程度上增加了。总之，通过改善学习条件，MPH被证明对多动症和合并症阅读障碍儿童的阅读过程有帮助，但MPH不能治愈阅读障碍。未来的研究应该在一项双盲临床试验中研究MPH对阅读的影响。

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《European journal of paediatric neurology: EJPN : official journal of the European Paediatric Neurology Society》 |2007年第1期|共8页
作者
Keulers EH; Hendriksen JG; Feron FJ; Wassenberg R; Wuisman-Frerker MG; Jolles J; Vles JS;
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正文语种 eng
中图分类儿科学;
关键词
Reading; Child attention deficit disorder; Dyslexia; 5; 10-dihydro-5-methylphenazine; 阅读; 阅读障碍;

机译：Reading;Child attention deficit disorder;Dyslexia;5;10-dihydro-5-methylphenazine;阅读;阅读障碍;

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1. Methylphenidate improves reading performance in children with attention deficit hyperactivity disorder and comorbid dyslexia: an unblinded clinical trial. [J] . Keulers EH, Hendriksen JG, Feron FJ, European journal of paediatric neurology: EJPN : official journal of the European Paediatric Neurology Society . 2007,第1期

机译：哌醋甲酯可改善患有注意力缺陷多动障碍和合并症的阅读障碍儿童的阅读能力：一项无盲临床试验。
2. Aripiprazole in children and adolescents with bipolar disorder comorbid with attention-deficit/hyperactivity disorder: a pilot randomized clinical trial. [J] . Tramontina S, Zeni CP, Ketzer CR, The journal of clinical psychiatry . 2009,第5期

机译：患有双相情感障碍的儿童和青少年中的阿立哌唑与注意力缺乏/多动症并存：一项随机临床试验。
3. Comparison of the efficacy of two different modified release methylphenidate preparations for children and adolescents with attention-deficit/hyperactivity disorder in a natural setting: comparison of the efficacy of Medikinet((R)) retard and Concerta((R))--a randomized, controlled, double-blind multicenter clinical crossover trial. [J] . Dopfner M, Ose C, Fischer R, Journal of child and adolescent psychopharmacology . 2011,第5期

机译：两种不同的哌醋甲酯缓释制剂在自然环境中对患有注意力缺陷/多动障碍的儿童和青少年的疗效比较：Medikinet®（R）和Concerta（R）的疗效比较，对照，双盲多中心临床交叉试验。
4. A Machine Learning Study of Comorbidity of Dyslexia and Attention Deficiency Hyperactivity Disorder [C] . Junaita Davakumar, Arul Siromoney International Conference on Computational Intelligence in Data Science . 2020

机译：综合带综合症和注意力缺陷症的机器学习研究
5. Effectiveness of methylphenidate and combined treatment (methylphenidate and psychosocial treatment) for Chinese children with attention-deficit/hyperactivity disorder in a community mental health center. [D] . So, Yuk-chi. 2005

机译：哌醋甲酯和联合治疗（哌醋甲酯和社会心理治疗）对中国社区精神卫生中心注意力不足/多动障碍儿童的有效性。
6. Effect of Atomoxetine Treatment on Reading and Phonological Skills in Children with Dyslexia or Attention-Deficit/Hyperactivity Disorder and Comorbid Dyslexia in a Randomized Placebo-Controlled Trial [O] . Sally Shaywitz, Bennett Shaywitz, Linda Wietecha, -1

机译：随机安慰剂对照试验中的阿托莫西汀治疗对阅读障碍或注意力缺乏/多动障碍和合并阅读障碍儿童的阅读和语音技能的影响
7. Effect of Atomoxetine Treatment on Reading and Phonological Skills in Children with Dyslexia or Attention-Deficit/Hyperactivity Disorder and Comorbid Dyslexia in a Randomized, Placebo-Controlled Trial [O] . Shaywitz, Sally, Shaywitz, Bennett, Wietecha, Linda, 2017

机译：随机，安慰剂对照试验中的阿托莫西汀治疗对阅读障碍或注意力缺乏/多动障碍和合并阅读障碍儿童的阅读和语音技能的影响

Methylphenidate improves reading performance in children with attention deficit hyperactivity disorder and comorbid dyslexia: an unblinded clinical trial.

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