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首页> 外文期刊>European journal of paediatric neurology: EJPN : official journal of the European Paediatric Neurology Society >Evaluation and management of bone health in children with epilepsy on long-term antiepileptic drugs: United Kingdom survey of paediatric neurologists.
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Evaluation and management of bone health in children with epilepsy on long-term antiepileptic drugs: United Kingdom survey of paediatric neurologists.

机译：长期抗癫痫药物治疗癫痫患儿的骨骼健康评估和管理：英国儿科神经科医生调查。

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BACKGROUND AND OBJECTIVE: Current evidence indicates long-term use of antiepileptic drugs (AEDs) is associated with impaired childhood bone health. The objective of this study was to ascertain the current clinical practice of paediatric neurologists managing children with epilepsy on long-term (>2 years) AED therapy, particularly against the UK Medicines and Healthcare products Regulatory Agency (MHRA) current recommendation of vitamin D supplementation in patients on long-term AEDs at-risk of impaired bone health. METHODS: An internet-based survey of UK paediatric neurologists who routinely see children with epilepsy (n = 95) covered clinicians' epilepsy case-load and reflection on their current clinical practice with estimation of the frequency with which they considered various bone health issues. Responses were graded as 'frequent'(>/=50%), 'sometimes'(25%-50%) and 'infrequent'(<25%). RESULTS: Overall response rate was 72/95 (76%). 3% frequently recommend prophylactic calcium and vitamin D supplementation, 6% frequently perform bone screening investigations, 7% frequently give bone health advice and 10% frequently enquire about skeletal risk factors. Clinical practices were not associated with epilepsy caseload (p-values 0.44-1). 84% infrequently performed bone health screening investigations. 54% of respondents indicated that, if performed, 100% would undertake bone profile, 64% 25(OH) Vitamin D, 18% PTH, 49% dual energy X-ray absorptiometry (DEXA) scan and 13% bone X-ray. CONCLUSIONS: The majority of paediatric neurologists do not routinely consider bone health related issues in children on long-term AEDs. Greater emphasis should be placed on vitamin D supplementation in these children.
机译：背景与目的：目前的证据表明，长期使用抗癫痫药与儿童骨骼健康受损有关。这项研究的目的是确定儿童神经科医师在长期（> 2岁）AED治疗中治疗癫痫儿童的当前临床实践，尤其是针对英国药物和保健产品监管局（MHRA）当前补充维生素D的建议长期使用AED的患者有骨骼健康受损的风险。方法：一项基于互联网的对英国小儿神经科医师的调查，他们常规看癫痫儿童（n = 95），涵盖了临床医生的癫痫病例数量，并对他们当前的临床实践进行了反思，并估计了他们考虑各种骨骼健康问题的频率。回答分为“频繁”（> / = 50％），“有时”（25％-50％）和“不频繁”（<25％）。结果：总体回应率为72/95（76％）。 3％的人经常建议补充预防性钙和维生素D，6％的人经常进行骨骼筛查，7％的人经常提供骨骼健康建议，10％的人询问骨骼危险因素。临床实践与癫痫病例数无关（p值为0.44-1）。 84％的人很少进行骨骼健康检查。 54％的受访者表示，如果执行，将进行100％的骨骼分析，64％的25（OH）维生素D，18％的PTH，49％的双能X线骨密度仪（DEXA）扫描和13％的骨骼X线。结论：大多数小儿神经科医师没有常规考虑长期AED患儿的骨骼健康相关问题。这些儿童应更加重视补充维生素D。

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