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首页> 外文期刊>European journal of paediatric neurology: EJPN : official journal of the European Paediatric Neurology Society >Population-based study of neuroimaging findings in children with cerebral palsy.
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Population-based study of neuroimaging findings in children with cerebral palsy.

机译：基于人群的脑瘫儿童神经影像学研究。

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BACKGROUND: Neuroimaging is currently recommended as a standard evaluation in children with cerebral palsy (CP). AIMS: Utilizing imaging findings from a population-based registry (REPACQ), the frequency and proportion of cerebral radiologic abnormalities in children CP over a four year birth cohort was investigated. METHODS: Descriptions of CT and MRI studies were extracted from the Registry dataset and classified into 10 distinct categories. RESULTS: Two hundred and thirteen children had imaging available (119 males, 94 females, mean age of 44 months [SD. +/- 14 months] at Registry inscription). Eighty seven percent of participants had documented cerebral abnormalities, the most common of which were periventricular white matter injury (PVWMI) (19.2%), diffuse gray matter injury (14.6%), cerebral vascular accident (CVA) (11.7%), and cerebral malformation (11.3%). Also, 18.8% of participants had non-specific radiologic findings and 13.1% of participants had normal imaging results. Severe CP (i.e. GMFCS Level IV-V) and spastic quadriplegic CP were significantly associated with the neuroimaging findings of gray matter injury, while spastic hemiplegic CP was association with CVA, and dyskinetic and spastic diplegic CP were both associated with normal and non-specific neuroimaging findings. CONCLUSIONS: Specific patterns of neuroimaging findings in children with CP were found to be associated with neurological subtype, CP severity (i.e. GMFCS Level) and other categorical variables.
机译：背景：目前，神经影像学被推荐作为脑瘫（CP）儿童的标准评估。目的：利用基于人群的登记系统（REPACQ）的影像学发现，对4岁出生的儿童CP中脑部放射学异常的发生频率和比例进行调查。方法：从Registry数据集中提取CT和MRI研究的描述，并分为10个不同的类别。结果：213名儿童进行了影像学检查（登记册上题为119例男性，94例女性，平均年龄为44个月[SD。+/- 14个月]）。 87％的参与者记录了脑部异常，最常见的是脑室白质损伤（PVWMI）（19.2％），弥散性灰质损伤（14.6％），脑血管意外（CVA）（11.7％）和脑部异常畸形（11.3％）。此外，有18.8％的参与者具有非特异性放射学发现，而13.1％的参与者具有正常的影像学检查结果。严重CP（即GMFCS IV-V级）和痉挛性四肢瘫痪CP与灰质损伤的神经影像学表现显着相关，而痉挛性偏瘫CP与CVA相关，运动障碍和痉挛性双腿CP均与正常和非特异性相关神经影像学发现。结论：发现患有CP的儿童的神经影像学发现的特定模式与神经学亚型，CP严重程度（即GMFCS水平）和其他分类变量有关。

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