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首页> 外文期刊>European journal of pediatrics >A detailed analysis of changes in serum C-reactive protein levels in neonates treated for bacterial infection.
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A detailed analysis of changes in serum C-reactive protein levels in neonates treated for bacterial infection.

机译：接受细菌感染治疗的新生儿血清C反应蛋白水平变化的详细分析。

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摘要

A prospective study was undertaken to characterize the rate of increase, time of peak values and rates of decrease in serum concentrations of C-reactive protein (CRP) in a group of infants treated for neonatal bacterial infection. A total of 176 consecutively admitted neonates with birth weight > 1500 g and without mechanical ventilation or central lines in situ, who received antibiotic therapy for suspected bacterial infection, were enrolled. The changes in serum CRP concentration in 60 of 63 infants who had CRP values above 20 mg/l 24-48 h after the beginning of treatment were analysed in detail. Initial increase rates in serum CRP levels of up to 4.5 mg/l per h were documented peak were reached at a mean of 19.5 h after antibiotic therapy had been initiated, but in some patients an increase in serum CRP levels occurred up to 40-48 h after the beginning of treatment. The mean serum half-life of CRP in infected neonates was 21 h (range 11.2-38 h). CONCLUSION: In neonates with bacterial infection (defined by a combination of clinical signs and increased C-reactive protein and immature-total quotient values) no differences in the overall pattern nor in any of the particular phases of the C-reactive protein response curves could be observed between neonates with positive (n = 13) or negative blood cultures (n = 47).
机译：进行了一项前瞻性研究，以表征一组接受新生儿细菌感染治疗的婴儿的C反应蛋白（CRP）血清浓度的升高速率，峰值时间和降低速率。总共入选了176例连续出生的新生儿，这些新生儿的出生体重> 1500 g，并且没有机械通气或原位中心线，接受了可疑细菌感染的抗生素治疗。开始治疗后，对63名CRP值超过20 mg / l 24-48 h的婴儿中的60名婴儿的血清CRP浓度变化进行了详细分析。抗生素治疗开始后平均19.5 h时，血清CRP水平最初升高的速率最高达到4.5 mg / l，但在某些患者中，血清CRP水平升高到40-48。开始治疗后h。 CRP在感染新生儿中的平均血清半衰期为21小时（范围11.2-38小时）。结论：在细菌感染的新生儿中（由临床体征和增加的C反应蛋白和未成熟总商值定义），总体模式或C反应蛋白反应曲线的任何特定阶段均无差异。在血培养阳性（n = 13）或阴性（n = 47）的新生儿之间观察到。

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