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首页> 外文期刊>European journal of gastroenterology and hepatology >Embracing complexity: what determines quality of life in inflammatory bowel disease?
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Embracing complexity: what determines quality of life in inflammatory bowel disease?

机译：拥抱复杂性：什么因素决定了炎症性肠病的生活质量？

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A subset of patients with inflammatory bowel disease have markedly impaired quality of life. In this issue, Mussell et al. report that patients' self-rated health status and disease-related concerns were determined at least as strongly by their habitual use of depressive coping patterns as by their disease activity. Although past disease severity may have confounded these results, the finding that quality of life is better for patients armed with a positive approach to problem-handling suggests that psychologically oriented interventions could have far-reaching benefits for selected patients. Since evidence is accumulating that stress and distress can worsen tissue inflammation and clinical course in animal models and in clinical populations with inflammatory bowel disease, we may dare to hope that interventions aimed at improving patients' stress tolerance, depressive symptoms, and coping capacities might not only improve perceived quality of life but could potentially decrease bowel inflammation and reduce some patients' need for toxic medications or surgery. Designing, applying, and evaluating such interventions should be a major item on the agenda of psychosomatic medicine in gastroenterology, and biological reductionism should be replaced by the biopsychosocial model.
机译：炎性肠病患者中有一部分患者的生活质量明显受损。在本期中，Mussell等。报告指出，患者的自我评价健康状况和与疾病相关的担忧至少是由他们习惯使用抑郁应对方式和疾病活动所决定的。尽管过去的疾病严重程度可能混淆了这些结果，但是发现发现，对于采用积极处理问题的方法的患者而言，生活质量更好，这一发现表明，以心理为导向的干预措施对某些患者可能具有深远的益处。由于越来越多的证据表明，压力和困扰可能会加剧动物模型和炎症性肠病临床人群的组织炎症和临床病程，因此我们可能不希望希望旨在改善患者的压力耐受性，抑郁症状和应对能力的干预措施只能改善感知的生活质量，但可能会减少肠炎并减少某些患者对有毒药物或手术的需求。设计，应用和评估此类干预措施应该是胃肠病学上心身医学议程上的主要议题，而生物还原主义应该被生物心身模型所取代。

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