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首页> 外文期刊>European journal of gastroenterology and hepatology >Diagnosis and grading of gastritis by non-invasive optical analysis.
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Diagnosis and grading of gastritis by non-invasive optical analysis.

机译：通过无创光学分析诊断和分级胃炎。

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OBJECTIVES: The precise identification of many diseases of the gastrointestinal tract requires the histological analysis of multiple biopsies of the lining mucosae, thus preventing an immediate diagnosis and the safe screening of the entire organ. To address these limitations, we developed a novel spectroscopic procedure for a real-time, non-invasive optical analysis of mucosae. METHODS: We have used a fibre-optic probe that monitors light propagation through small tissue volumes to evaluate the antral and fundic mucosa of 51 patients that underwent gastroscopy for symptoms of dyspepsia. Several optical coefficients were computed from the recorded light reflectance, and confronted to the diagnosis made by an expert gastroscopist at the time of the clinical examination. Both evaluations were then validated by comparison with the histological diagnosis of a pathologist who screened biopsies taken at the sites of the optical measurements. RESULTS: We report that the optical procedure discriminated normal and pathological gastric mucosae with a higher sensitivity and specificity than endoscopic diagnosis. We also show that the changes in light-scattering coefficient, which permitted the optical diagnosis of gastritis alterations, were indirectly correlated with the extent of inflammatory infiltration of the mucosa and detected mucosal alterations mild enough to escape endoscopic detection. CONCLUSIONS: The results show that, in a normal clinical setting, the optical in vivo analysis provided by our system detects alterations typical of gastritis, and allow for their graded scoring with a specificity and sensitivity that compare well with those of standard histology, while avoiding the invasiveness of the latter procedure. The method is adaptable to the screening of other types of lesions and mucosae and, hence, should prove useful in improving available diagnostic approaches.
机译：目的：要准确识别许多胃肠道疾病，需要对内膜粘膜的多个活检组织进行组织学分析，从而阻止立即诊断和对整个器官进行安全筛查。为了解决这些局限性，我们开发了一种新颖的光谱程序，用于粘膜的实时，非侵入性光学分析。方法：我们使用了一种光纤探头，该探头监测通过小组织量传播的光，以评估51例胃镜检查的消化不良症状患者的胃窦和胃底黏膜。从记录的光反射率计算出几个光学系数，并在临床检查时面对专业的胃镜医师的诊断。然后，通过与病理学家的组织学诊断比较来验证这两种评估，病理学家筛选了在光学测量部位采集的活组织检查。结果：我们报告说，光学手术能以比内窥镜诊断更高的灵敏度和特异性来区分正常和病理性胃粘膜。我们还表明，光散射系数的变化（可以对胃炎的改变进行光学诊断）与粘膜的炎性浸润程度间接相关，并且所检测到的粘膜改变轻度足以逃避内窥镜检查。结论：结果表明，在正常临床情况下，我们的系统提供的光学体内分析能够检测出典型的胃炎改变，并使其分值评分具有与标准组织学比较好的特异性和敏感性，同时避免了后一种手术的侵入性。该方法适用于其他类型的病变和粘膜的筛查，因此，应被证明可用于改善可用的诊断方法。

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