• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>European journal of gastroenterology and hepatology >Quality of life and outcome of ultrasound-guided laser interstitial thermo-therapy for non-resectable liver metastases of colorectal cancer.
【24h】

Quality of life and outcome of ultrasound-guided laser interstitial thermo-therapy for non-resectable liver metastases of colorectal cancer.

机译：结肠癌不可切除的肝转移的超声引导激光间隙热疗的生活质量和结果。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

OBJECTIVE: Patients with non-resectable liver metastases of colorectal cancer have poor prognosis and are mainly treated by palliative chemotherapy. Laser interstitial thermo-therapy is an innovative minimal invasive procedure for local tumour destruction within solid organs. The aim of the study was to investigate quality of life and outcome of ultrasound-guided laser interstitial thermo-therapy (US-LITT) in patients with liver metastases of colorectal cancer. METHODS: In this prospective non-randomized study, 45 patients with liver metastases of colorectal cancer were palliatively treated by US-LITT. Patient survival was analysed by the Kaplan-Meier method and the quality of life by questionnaire C30 of the European Organisation for Research and Treatment of Cancer before, and 1 week, 1 month, and 6 months after initiation of US-LITT. RESULTS: Median survival after initiation of US-LITT was 8.5 +/- 0.7 months with a range of 1.5-18 months. Body weight was constant 1 month after US-LITT. In the multivariate analyses, quality-of-life symptoms and functioning scales did not deteriorate in patients alive at 6 months after initiation of US-LITT. Univariate analyses outlined a significant increase of the pain subscale before and at 1 week after US-LITT. CONCLUSIONS: This study first describes the quality of life in patients with liver metastases of colorectal cancer treated by US-LITT. Potential benefits of the minimal invasive procedure could be prolonged survival time by preserved quality of life, but this first impression needs to be verified in a comparative study.
机译：目的：大肠癌不可切除的肝转移患者预后较差，主要采用姑息化疗治疗。激光间隙热疗是一种创新的微创手术，可用于破坏实体器官内的局部肿瘤。这项研究的目的是调查大肠癌肝转移患者的超声引导激光间质热疗法（US-LITT）的生活质量和结果。方法：在这项前瞻性非随机研究中，采用US-LITT姑息治疗45例结直肠癌肝转移患者。在开始使用US-LITT之前，之后1周，1个月和6个月，通过Kaplan-Meier方法分析患者的生存情况，并通过欧洲癌症研究与治疗组织的问卷C30评估生活质量。结果：US-LITT启动后的中位生存期为8.5 +/- 0.7个月，范围为1.5-18个月。 US-LITT后1个月体重保持恒定。在多变量分析中，US-LITT开始后6个月活着的患者的生活质量症状和功能量表并未恶化。单因素分析概述了US-LITT之前和之后1周疼痛分量表的显着增加。结论：本研究首先描述了US-LITT治疗的结直肠癌肝转移患者的生活质量。微创手术的潜在好处可以通过保持生活质量来延长生存时间，但是这种第一印象需要在比较研究中得到验证。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号