• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>European journal of gastroenterology and hepatology >Pantoprazole based therapies in Helicobacter pylori eradication: a systematic review and meta-analysis.
【24h】

Pantoprazole based therapies in Helicobacter pylori eradication: a systematic review and meta-analysis.

机译：根除幽门螺杆菌的基于top托拉唑的疗法：系统评价和荟萃分析。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

AIM: To perform a systematic review on the efficacy of pantoprazole based therapies in Helicobacter pylori eradication, and to conduct a meta-analysis comparing the efficacy of pantoprazole and other proton pump inhibitors (PPIs) when co-prescribed with antibiotics. METHODS: Studies evaluating pantoprazole combined with antibiotics were considered. Only randomized clinical trials comparing pantoprazole and other PPIs when co-prescribed with antibiotics, and differing only in the PPI (pantoprazole vs other), were eligible for inclusion in the meta-analysis. Bibliographical searches in several electronic databases, and manual search of abstracts from congresses, were conducted. The percentage (weighted mean) of patients with eradication success was calculated. Meta-analysis was performed combining the odds ratios (ORs) of the individual studies in a global OR. RESULTS: The mean eradication rate with pantoprazole plus clarithromycin for 14 days was 60%. Cure rates with 7 day pantoprazole based triple regimens were higher: pantoprazole, amoxicillin and clarithromycin (78%); pantoprazole, clarithromycin and nitroimidazole (84%); and pantoprazole, amoxicillin and nitroimidazole (74%). Twelve studies comparing pantoprazole and other PPIs were selected for the meta-analysis, including 534 and 603 patients, respectively. The mean eradication rate for H. pylori using pantoprazole plus antibiotics was 83%, and 81% when other PPIs were used (OR = 1; 95% confidence interval (CI) from 0.61 to 1.64). When sub-analysis was performed, including only studies comparing pantoprazole with omeprazole, or pantoprazole with lansoprazole, differences were also statistically non-significant. The meta-analysis of the six studies prescribing equivalent doses of all PPIs demonstrated similar results with pantoprazole and with other PPIs (OR = 1.07; 95% CI from 0.71 to 1.62), the results being statistically homogeneous. CONCLUSIONS: Pantoprazole achieves similar cure rates to those of omeprazole and lansoprazole when co-prescribed with antibiotics for the eradication of H. pylori infection.
机译：目的：对基于top托拉唑的治疗方法在根除幽门螺杆菌中的疗效进行系统评价，并进行荟萃分析，比较pan托拉唑和其他质子泵抑制剂（PPI）与抗生素共同处方时的疗效。方法：考虑了评估top托拉唑联合抗生素的研究。只有在与抗生素共同处方时比较pan托拉唑和其他PPI且仅在PPI方面有所不同（top托拉唑与其他）的随机临床试验才有资格纳入荟萃分析。在几个电子数据库中进行了书目检索，并从国会中人工检索了摘要。计算出根除成功患者的百分比（加权平均值）。荟萃分析是在整体OR中结合各个研究的优势比（OR）进行的。结果：pan托拉唑联合克拉霉素治疗14天的平均根除率为60％。 7天以top托拉唑为基础的三联疗法的治愈率更高：pan托拉唑，阿莫西林和克拉霉素（78％）; top托拉唑，克拉霉素和硝基咪唑（84％）;以及top托拉唑，阿莫西林和硝基咪唑（74％）。选择12项比较top托拉唑和其他PPI的研究进行荟萃分析，分别包括534和603例患者。使用pan托拉唑加抗生素对幽门螺杆菌的平均根除率为83％，而使用其他PPI时的根除率则为81％（OR = 1; 95％置信区间（CI）从0.61至1.64）。当进行亚分析时，仅包括将潘托拉唑与奥美拉唑或潘托拉唑与兰索拉唑进行比较的研究，差异在统计学上也无统计学意义。对所有PPI剂量相等的六项研究进行的荟萃分析显示，与pan托拉唑和其他PPI相似的结果（OR = 1.07; 95％CI从0.71至1.62），结果在统计上是一致的。结论：与抗生素共同处方用于根除幽门螺杆菌感染时，Pan托拉唑可达到与奥美拉唑和兰索拉唑相似的治愈率。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号