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首页> 外文期刊>European journal of gastroenterology and hepatology >Correlation of alcohol consumption with liver histological features in non-cirrhotic patients.
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Correlation of alcohol consumption with liver histological features in non-cirrhotic patients.

机译：非肝硬化患者饮酒与肝组织学特征的关系。

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BACKGROUND AND AIMS: The association between alcohol consumption and the risk of liver disease remains unclear. The aim of our study was to determine liver morphological features directly related to the mean lifetime daily alcohol intake (LTDAI) in non-cirrhotic patients. METHODS: Medical records of all consecutive patients who reported alcohol consumption up to the time of hospital admission and who had undergone a liver biopsy in the Gastroenterology Unit of the University Hospital Centre of Tirana (Albania), were reviewed. Patients with established cirrhosis and/or with other possible causes of liver damage were excluded by the study. RESULTS: The histological features revealed in the biopsy samples of 51 non-cirrhotic patients were: steatosis in 46 patients (91%), six of whom (13%) showed also alcoholic foamy degeneration; alteration of hepatocytes in 40 patients (78%), diffuse mononuclear inflammation in 37 patients (73%), polymorphonuclear inflammation in 11 patients (22%) and perivenular fibrosis in 18 patients (35%). Diffuse steatosis was directly correlated with alcohol consumption (P<0.01). No association was found between alcohol consumption and the presence of degenerative alterations of hepatocytes, Mallory bodies or hepatocellular necrosis. Fibrosis was more prevalent in patients who reported a LTDAI >/=80 g in comparison with patients who reported a LTDAI >/=40 to <80 g (48% vs 25%; P<0.05). CONCLUSION: In non-cirrhotic patients liver steatosis and fibrosis were more common features among patients who reported a higher alcoholic consumption, but no clear-cut association between typical histological features of alcoholic liver disease and alcohol consumption was found.
机译：背景与目的：饮酒与肝病风险之间的关联仍不清楚。我们研究的目的是确定与非肝硬化患者的平均终生每日酒精摄入量（LTDAI）直接相关的肝脏形态特征。方法：回顾了在地拉那大学医院中心（阿尔巴尼亚）的胃肠病科，直到入院时为止一直报告饮酒并进行了肝活检的所有连续患者的病历。该研究排除了已确定的肝硬化和/或其他可能的肝损害原因的患者。结果：51例非肝硬化患者的活检样本显示的组织学特征为：46例（91％）脂肪变性，其中6例（13％）也显示出酒精性泡沫变性;肝细胞改变40例（78％），弥漫性单核炎症37例（73％），多形核炎症11例（22％）和室周纤维化18例（35％）。弥漫性脂肪变性与饮酒直接相关（P <0.01）。在饮酒与肝细胞，马洛氏体的变性改变或肝细胞坏死的存在之间未发现关联。与报告LTDAI> / = 40至<80 g的患者相比，报告LTDAI> / = 80 g的患者中纤维化更为普遍（48％vs 25％; P <0.05）。结论：在非肝硬化患者中，肝脂肪变性和纤维化是酒精摄入量较高的患者中较常见的特征，但未发现酒精性肝病的典型组织学特征与饮酒之间存在明确的关联。

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