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首页> 外文期刊>European journal of gastroenterology and hepatology >PCR in Helicobacter spp. diagnostic in extragastric malignancies of digestive system
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PCR in Helicobacter spp. diagnostic in extragastric malignancies of digestive system

机译：幽门螺杆菌中的PCR。诊断消化系统胃外恶性肿瘤

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Recognition of Helicobacter pylori as an important factor in genesis of gastric adenocarcinoma lead to a large number of studies concerning potential role of Helicobacter spp. in the development of extragastric digestive malignancies. The serological studies indicated possible localizations in the digestive system being from interest in enlightening Helicobacter spp. carcinogenic potential. The PCR obtruded itself as a gold standard in proving existence of actual correlation. In this review, the authors have examined studies conducted in the last 10 years examining Helicobacter spp. correlation with extragastric digestive carcinogenesis. Studies have been observed in four groups referring to hepatic carcinoma, bile duct cancer, pancreatic cancer, and colon cancer. The results of these researches have shown that there is a strong correlation between Helicobacter spp. colonization and primary liver tumors as well as bile duct tumors, whereas conclusions made by authors examining pancreatic cancer are contradictory and demands further investigation. No correlation between Helicobacter spp. and colon cancer have been proven. The PCR subtype most widely used in studies included in this review was nested PCR, whereas genes targeted most frequently for amplification are 16S rDNA of Helicobacter spp. and UreA gene or cagA gene of H. pylori. During the last 10 years PCR has proven itself as a sovereign method for Helicobacter spp. diagnostic in extragastric organs in the digestive system. Knowledge and experiences obtained in this domain could be encouraging for researchers in analogous fields of interest.
机译：幽门螺杆菌是胃腺癌发生中的重要因素，这一认识引起了关于幽门螺杆菌潜在作用的大量研究。在胃外消化系统恶性肿瘤的发展中。血清学研究表明，消化系统中可能存在局部化是由于启发性幽门螺杆菌引起的。致癌潜力。在证明存在实际相关性时，PCR本身已成为金标准。在这篇评论中，作者检查了过去十年中检查幽门螺杆菌的研究。与胃外消化道癌变的相关性。已经在涉及肝癌，胆管癌，胰腺癌和结肠癌的四个组中观察到研究。这些研究的结果表明，幽门螺杆菌之间有很强的相关性。定植和原发性肝肿瘤以及胆管肿瘤，而检查胰腺癌的作者得出的结论是矛盾的，需要进一步研究。幽门螺杆菌之间没有相关性。和结肠癌已被证明。在本综述中，研究中使用最广泛的PCR亚型是巢式PCR，而扩增最常靶向的基因是幽门螺杆菌的16S rDNA。和幽门螺杆菌的UreA基因或cagA基因。在过去的十年中，PCR已证明自己是幽门螺杆菌的主要方法。诊断消化系统的胃外器官。在这一领域中获得的知识和经验可能会吸引类似兴趣领域的研究人员。

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