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首页> 外文期刊>European journal of gynaecological oncology >Post-radiation Pap smear for Chinese patients with cervical cancer: a ten-year follow-up.
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Post-radiation Pap smear for Chinese patients with cervical cancer: a ten-year follow-up.

机译：中国宫颈癌患者放疗后宫颈涂片检查：十年随访。

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BACKGROUND: To study the performance of routine follow-up Pap smears after curative radiotherapy (RT) for Chinese cervical cancer (CC) patients. METHODS: In 1996, 50 patients with non-metastatic CC received curative RT. Forty-six patients had routine follow-up Pap smears and constituted the study group. Details regarding clinical characteristics were retrospectively abstracted. Pap smear results were obtained via national Pap smear database linkage and chart review. The Pap smear results during recurrence-free survival (RFS) were analyzed and compared with clinical outcomes to study the performance characteristics. RESULTS: After 34 (2 approximately 105) months' median follow-up, the clinical outcomes were isolated central recurrence (ICR), other recurrence (OR), and no evidence of disease (NED) for six, 20, and 20 patients, respectively. During 22 months' median RFS (range 2-105), 422 Pap smears (including missing data, n = 33) were performed. Most of the Pap smear results were within normal limits (65.8%) or benign (reactive changes or atrophy with inflammation) (25.2%). Atypical cells, low-grade squamous intraepithelial lesion (LSIL), high-grade intraepithelial lesion (HSIL), and carcinoma were found in ten (2.6%), 11 (2.8%), 11 (2.8%), and three (0.8%) specimens, respectively. Follow-up of the 21 atypical cells/LSIL smears among seven patients revealed five NED with normal/benign smears, one NED with HSIL and one OR with HSIL. Follow-up of the 11 HSIL smears among four patients revealed two ICR, one OR and one NED with HSIL. Follow-up of the three carcinoma smears revealed three ICR (one followed by HSIL in a repeat Pap smear before ICR). The sensitivity for the detection of ICR by carcinoma smears was 50%, with a specificity and positive predictive value (PPV) of 100%. CONCLUSION: Few (approximately 3%) of the routine follow-up Pap smears after CC patients receiving curative RT were HSIL/carcinoma, but most (4/6) of these patients turned out to be ICR.
机译：背景：目的：研究中国宫颈癌（CC）患者接受根治性放疗（RT）后常规的子宫颈抹片检查的表现。方法：1996年，50例非转移性CC患者接受了治愈性RT。 46例患者进行了常规的子宫颈抹片检查，构成了研究组。回顾性地提取有关临床特征的细节。子宫颈抹片检查结果是通过全国子宫颈抹片检查数据库链接和图表审查获得的。分析了无复发生存期（RFS）中的子宫颈抹片检查结果，并将其与临床结果进行比较以研究其性能特征。结果：在中位随访34（2约105）个月后，分别有6例，20例和20例患者的临床结局为中心复发（ICR），其他复发（OR）和无疾病证据（NED），分别。在22个月的RFS中位数（范围2-105）中，进行了422例子宫颈抹片检查（包括缺失数据，n = 33）。大部分子宫颈抹片检查结果均在正常范围内（65.8％）或良性（反应性改变或炎症性萎缩）（25.2％）。在十个（2.6％），11个（2.8％），11个（2.8％）和三个（0.8％）中发现非典型细胞，低度鳞状上皮内病变（LSIL），高度上皮内病变（HSIL）和癌）标本。对7例患者的21个非典型细胞/ LSIL涂片进行了随访，发现5例NED涂片正常/良性，1例NED涂HSIL，1例OR涂HSIL。对四名患者进行的11例HSIL涂片的随访发现，有2例ICR，1例OR和1例NED伴HSIL。对这三种癌变涂片的随访发现了三份ICR（在ICR之前，在重复的子宫颈涂片检查中，继之以HSIL）。通过癌涂片检测ICR的灵敏度为50％，特异性和阳性预测值（PPV）为100％。结论：接受根治性放疗的CC患者在常规的Pap随访涂片检查中很少（约3％）是HSIL /癌，但这些患者中大多数（4/6）是ICR。

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