Primary malignant melanoma of the vagina is a very rare, but very aggressive tumor. We describe a case of primary vaginal melanoma and review the literature. The patient, a 73-year-old, gravida 2, para 2 postmenopausal Greek woman, presented with abnormal vaginal bleeding for 30 days. On vaginal examination there was a 5.5 x 5 x 2 cm raised, ulcerated and irregular lesion on the posterior vaginal wall. Pathology examination of the entire specimen demonstrated a nodular vaginal melanoma. The histologic diagnosis was confirmed by positive immunostaining. The patient began postoperative immunotherapy with interferon-a2b. She died 25 months later because of cerebral metastases. In conclusion, the prognosis of vaginal melanoma is very poor, despite the treatment modality, because most cases are diagnosed at a late stage.
展开▼
机译：阴道原发性恶性黑色素瘤是一种非常罕见但非常具有侵略性的肿瘤。我们描述一例原发性阴道黑色素瘤并复习文献。该患者是一名73岁的孕妇gravida 2，第2段，希腊绝经后妇女，出现异常阴道出血30天。阴道检查时，阴道后壁上有5.5 x 5 x 2 cm的凸起，溃疡和不规则病变。整个标本的病理检查显示为结节性阴道黑色素瘤。阳性免疫染色证实了组织学诊断。患者开始用干扰素-a2b进行术后免疫治疗。 25个月后，她因脑转移而死亡。总之，尽管有治疗方法，但阴道黑素瘤的预后很差，因为大多数病例是在晚期诊断出来的。
展开▼
