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首页> 外文期刊>European journal of gynaecological oncology >Preoperative diagnosis of malignant transformation in mature cystic teratoma of the ovary.
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Preoperative diagnosis of malignant transformation in mature cystic teratoma of the ovary.

机译：卵巢成熟性囊性畸胎瘤的恶性转化的术前诊断。

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OBJECTIVE: Malignant transformation of mature cystic teratomas (MCT) of the ovary is extremely rare. There are no established criteria of diagnosis before surgery for carcinoma arising from MCT of the ovary. Thus, we analyzed retrospectively tumor size and preoperative values of tumor markers in patients with MCT and investigated the possibility of preoperative diagnosis. METHODS: This was a retrospective case series of 278 patients with MCT of the ovary. Data were obtained from hospital charts and the pathology registry. Average tumor size (greatest diameter) was determined by the preoperative findings of both MRI and ultrasound examination. RESULTS: Malignant transformation was seen in five patients (11%) among those whose tumor was > or = 10 cm in diameter, four patients (23%) among those whose pretreatment serum SCC level was > or = 2.0 ng/ml, two patients (13%) among those over 60 years of age and five patients (2%) with a tumor on one side. Mean tumor size and serum SCC level were significantly higher than those of benign MCT. CONCLUSIONS: We conclude that patients over 60 years old who have unilateral MCT with SCC value of < or = 2.0 ng/ml and > or = 10 cm tumors may be a high-risk group for malignant transformation.
机译：目的：卵巢成熟性囊性畸胎瘤（MCT）的恶性转化极为罕见。对于卵巢MCT引起的癌，术前尚无诊断标准。因此，我们回顾性分析了MCT患者的肿瘤大小和肿瘤标志物的术前价值，并探讨了术前诊断的可能性。方法：这是一例回顾性病例系列，涉及278例卵巢MCT患者。数据从医院病历和病理登记处获得。平均肿瘤大小（最大直径）由MRI和超声检查的术前发现确定。结果：在肿瘤直径≥10 cm的患者中有5例（11％）发生了恶变，在治疗前血清SCC水平≥2.0 ng / ml的患者中有4例（23％）发生了恶变。 （13％）在60岁以上的人群中，五名患者（2％）一侧患有肿瘤。平均肿瘤大小和血清SCC水平显着高于良性MCT。结论：我们得出结论，单侧MCT≥60 ng / ml且≥10 cm肿瘤的单侧MCT的60岁以上患者可能是恶性转化的高危人群。

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