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首页> 外文期刊>European journal of gynaecological oncology >Thoracic metastases from breast cancer: a single-institution's experience.
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Thoracic metastases from breast cancer: a single-institution's experience.

机译：乳腺癌的胸腔转移：单一机构的经验。

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OBJECTIVE: Thoracic metastasis from breast cancer (TMBC) is a relatively uncommon condition, and few reports of its therapeutic palliation and patient outcomes exist. We therefore reviewed retrospectively our radiotherapeutic experience of TMBC. METHODS: Between 1981 and 2003, 19 patients were treated with radiation (with doses raging from 10 Gy to 50 Gy) for palliation of TMBC. RESULTS: The mean age was 55.4 years. Mediastinal lymph node disease was the most common form of TMBC. TMBC developed within five years of breast cancer diagnoses in 11 patients (58%). Among the evaluable symptomatic individuals, subjective palliation was complete in 78% of the cases. The complete objective response (e.g., complete resolution of clinically manifested superior vena caval obstruction or imaging-demonstrated atelectasis) rate was 50%. There was no significant difference in survival between patients presenting with airway obstruction and women who were not in respiratory distress, asymptomatic and symptomatic patients, and women with and without concurrent extrathoracic metastases. CONCLUSION: Although the prognosis of women with TMBC was quite ominous, radiotherapy should be considered in very symptomatic patients because justifiable palliation can be effected in some individuals.
机译：目的：乳腺癌（TMBC）的胸腔转移是一种相对罕见的疾病，很少有关于其治疗缓解和患者预后的报道。因此，我们回顾性地回顾了我们的TMBC放射治疗经验。方法：1981年至2003年间，对19例患者进行了放射治疗（剂量范围从10 Gy到50 Gy）以缓解TMBC。结果：平均年龄为55.4岁。纵隔淋巴结病是TMBC最常见的形式。 TMBC在乳腺癌诊断后的五年内发展为11位患者（58％）。在可评估的有症状个体中，有78％的病例完成了主观缓解。完全客观反应（例如，临床表现出的上腔静脉阻塞或影像学证实的肺不张的完全解决）率为50％。表现为气道阻塞的患者和没有呼吸窘迫的妇女，无症状和有症状的妇女以及有和没有并发胸外转移的妇女之间的生存率无显着差异。结论：尽管TMBC妇女的预后很不祥，但对有症状的患者应考虑放疗，因为在某些个体中可实现合理的缓解。

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