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首页> 外文期刊>European journal of gynaecological oncology >Histamine and its metabolizing enzymes in tissues of primary ductal breast cancer.
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Histamine and its metabolizing enzymes in tissues of primary ductal breast cancer.

机译：组胺及其代谢酶在原发性导管癌的组织中。

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OBJECTIVES: The aim of the study was to evaluate histamine concentrations in plasma and tissues of breast cancers depending on the activity of histamine metabolic enzymes in neoplasmatic tissues of the breast gland. MATERIAL AND METHODS: In 95 women aged 38-70 years the concentration of histamine in the plasma by the immunoenzymatic method, the concentration of histamine in breast cancer tissues and metabolism enzymes of histamine: histidine decarboxylase, decarboxylase of aromatic L-amino acid, N-histamine methyltransferase, monoamine oxydase B, diamine oxydase determined using an isotope technique were assessed. The 24-hour excretion of N-methylimidazolacetate acid was evaluated by the chromatography method. RESULTS: Significant increases were found of histamine concentrations in plasma tissues of ductal breast cancers, activity of histidine decarboxylase, aromatic L-amino acid and histamine methyltransferase. CONCLUSIONS: 1. Concentrations of histamine in plasma is dependent on the concentration of histamine in the tissues of ductal breast cancers. 2. Significant increases of histamine in cancerous tissues of ductal breast cancer could suggest the participation of this monoamine in the development of breast cancer. 3. The increase of histamine concentrations in ductal breast cancer tissues can be connected with disturbances in the balance between synthesis and enzymatic activation of this monoamine. 4. The concentration of histamine in plasma of women with ductal breast cancers is dependent on the number of lymph nodes and grade of histological malignancy.
机译：目的：本研究的目的是根据乳腺肿瘤组织中组胺代谢酶的活性来评估乳腺癌血浆和组织中组胺的浓度。材料与方法：采用免疫酶法在95名年龄在38-70岁的女性血浆中组胺的浓度，乳腺癌组织中组胺的浓度以及组胺的代谢酶：组氨酸脱羧酶，芳香族L-氨基酸的脱羧酶，N评估了使用同位素技术测定的-组胺甲基转移酶，单胺氧化酶B，二胺氧化酶。通过色谱法评价N-甲基咪唑乙酸的24小时排泄量。结果：乳腺导管癌血浆组织中的组胺浓度，组氨酸脱羧酶，芳香族L-氨基酸和组胺甲基转移酶活性显着增加。结论：1.血浆中组胺的浓度取决于乳腺导管癌组织中组胺的浓度。 2.乳腺导管癌癌组织中组胺的显着增加可能表明这种单胺参与了乳腺癌的发展。 3.乳腺导管癌组织中组胺浓度的增加可能与这种单胺的合成和酶促活化之间的平衡紊乱有关。 4.乳腺导管癌女性血浆中组胺的浓度取决于淋巴结的数量和组织学恶性程度。

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