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首页> 外文期刊>European journal of gastroenterology and hepatology >Short article: Successful faecal coliform sensitivity-based oral ertapenem therapy for chronic antibiotic-refractory pouchitis: a case series
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Short article: Successful faecal coliform sensitivity-based oral ertapenem therapy for chronic antibiotic-refractory pouchitis: a case series

机译：短篇文章：成功的基于粪便大肠菌群敏感性的口服厄他培南治疗慢性抗生素难治性囊炎：病例系列

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摘要

Pouchitis is a common complication of restorative proctocolectomy for ulcerative colitis, and a proportion of patients develop a refractory course. The treatment of chronic antibiotic-refractory pouchitis (CARP) is challenging, and treatment failure is often a cause of pouch excision. We report on a series of three patients with CARP who were treated with oral ertapenem following faecal coliform sensitivity testing. There was an improvement in the pouchitis disease activity index in all three patients [pretreatment pouch disease activity index, median 13 (range: 10-14); post-treatment pouch disease activity index, median 1 (range: 1-3)]. Identification of faecal coliform sensitivity and treatment with oral ertapenem might be helpful in patients with CARP.
机译：囊炎是溃疡性结肠炎的恢复性直肠结肠切除术的常见并发症，一部分患者发展为难治性病程。慢性抗生素难治性囊炎（CARP）的治疗具有挑战性，并且治疗失败通常是造成囊袋切除的原因。我们报告了三例经粪便大肠菌群敏感性测试后口服厄他培南治疗的CARP患者。 3例患者的囊炎疾病活动指数均有改善[治疗前囊肿疾病活动指数，中位数13（范围：10-14）;治疗后眼袋疾病活动指数，中位数1（范围：1-3）]。粪大肠菌群敏感性的鉴定和口服厄他培南治疗可能对CARP患者有所帮助。

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