...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>European journal of gastroenterology and hepatology >Influence of corticotropin-releasing hormone on gastric sensitivity and motor function in healthy volunteers.
【24h】

Influence of corticotropin-releasing hormone on gastric sensitivity and motor function in healthy volunteers.

机译：促肾上腺皮质激素释放激素对健康志愿者胃敏感性和运动功能的影响。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

BACKGROUND: As stress may be involved in the generation of functional dyspeptic symptoms, we evaluated the effect of the stress hormone, corticotropin-releasing hormone, on proximal stomach function. Twelve healthy volunteers [six women; 23 years (20-26 years)] underwent a barostat study on 2 days. During the infusion of corticotropin-releasing hormone (2.3 microg/kg/h) or saline, a stepwise distension protocol was performed followed by ingestion of a liquid meal (Nutridrink, 200 ml, 300 kcal). RESULTS: Corticotropin-releasing hormone infusion induced a significant increase in cortisol levels and basal volumes compared with placebo. The threshold for discomfort, meal-induced accommodation, dyspeptic symptoms, heart rate and blood pressure were all not significantly altered by corticotropin-releasing hormone infusion. CONCLUSION: In healthy volunteers, peripheral infusion of corticotropin-releasing hormone reduces basal fundic tone, but has no effect on meal-induced accommodation or visceral sensitivityto gastric distension. Our findings suggest that in healthy volunteers, peripheral corticotropin-releasing hormone seems not to be involved in the onset of dyspeptic symptoms.
机译：背景：由于压力可能与功能性消化不良症状的产生有关，因此我们评估了压力激素，促肾上腺皮质激素释放激素对近端胃功能的影响。 12名健康志愿者[6名妇女; 23岁（20-26岁）]进行了2天的恒压研究。在输注促肾上腺皮质激素释放激素（2.3 microg / kg / h）或盐水的过程中，进行了逐步扩张的方案，然后摄入了液态粉（Nutridrink，200 ml，300 kcal）。结果：与安慰剂相比，促肾上腺皮质激素释放激素的注入引起皮质醇水平和基础体积的显着增加。促肾上腺皮质激素释放激素的注入并没有显着改变不适感，进餐引起的不适，消化不良症状，心率和血压的阈值。结论：在健康志愿者中，外周滴注促肾上腺皮质激素释放激素可降低基础胃底张力，但对进餐引起的适应性或内脏对胃胀气的敏感性没有影响。我们的研究结果表明，在健康的志愿者中，周围皮质激素释放激素似乎与消化不良症状的发作无关。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号